ALEXIS Biochemicals: Emetine . dihydrochloride

ALX-350-092

Revised 03-Apr-08

Emetine . dihydrochloride
SYNONYMS	6’,7’,10,11-Tetramethoxyemetan . 2HCl
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - DNA Replication Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-092-M050		50 mg	10.00 USD

Product Specification

FORMULA:	C₂₉H₄₀N₂O₄ . 2HCl
MW:	480.7 . 73.0
CAS NUMBER:	316-42-7
MERCK INDEX:	14: 3559
SOURCE/HOST:	Isolated from ground roots of Uragoga ipecacuanha.
PURITY:	≥98%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light. Hygroscopic.
HAZARD:	TOXIC.

Product Description

Irreversibly blocks protein synthesis by inhibiting the movement of ribosome along the mRNA. Induces hypotension by blocking adrenoreceptors. Inhibits DNA replication in the early S phase. Inhibits HIF-1 activation by hypoxia. Induces apoptosis in leukemia cells. Antiamebic.

Product Specific Literature References

Inhibitors of protein biosynthesis. V. Effects of emetine on protein and nucleic acid biosynthesis in HeLa cells: A.P. Grollman; J. Biol. Chem. 243, 4089 (1968) Abstract
Cytometric analysis of DNA replication inhibited by emetine and cyclosporin A:: A: T. Schweighoffer, et al.; Histochemistry 96, 93 (1991) Abstract
Emetine allows identification of origins of mammalian DNA replication by imbalanced DNA synthesis, not through conservative nucleosome segregation: W.C. Burhans, et al.; EMBO J. 10, 4351 (1991) Abstract
Role of newly synthesized MHC class II molecules in antigen-specific antigen presentation by B cells: T. Kokuho, et al.; Immunobiology 193, 42 (1995) Abstract
Terpenoid tetrahydroisoquinoline alkaloids emetine, klugine, and isocephaeline inhibit the activation of hypoxia-inducible factor-1 in breast tumor cells: Y.D. Zhou, et al.; J. Nat. Prod. 68, 947 (2005) Abstract
The alkaloid emetine as a promising agent for the induction and enhancement of drug-induced apoptosis in leukemia cells: M. Moller, et al.; Oncol. Rep. 18, 737 (2007) Abstract
Characteristics of apoptosis induction by the alkaloid emetine in human tumour cell lines: M. Moller & M. Wink; Planta Med. 73, 1389 (2007) Abstract

Further Categories Containing This Product:

Other Toxins • Hypoxia-inducible Factor [HIF]/Related Products • Parasitic Diseases Other Products • Adrenergics & Adrenergic Receptors/Related Products • DNA Replication Inhibitors • Translation Inhibitors • Natural Products - Other Anti-infective Agents • Natural Products - Apoptosis Inducers & Inhibitors • Alkaloids • Natural Products for Neurological Research

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