© 2008 Alexis Corporation
ALX-380-280
Revised 08-Apr-08
Amphotericin B
SYNONYMS
Fungizone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics Other Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-380-280-M250
250 mg
65.00 USD
Product Specification
FORMULA:
C
47
H
73
NO
17
MW:
924.1
CAS NUMBER:
1397-89-3
MERCK INDEX:
14:
585
RTECS:
BU2625000
SOURCE/HOST:
Isolated from
Streptomyces sp
.
APPEARANCE:
Yellow to orange powder.
PURITY DETAIL:
Contains 50% sodium deoxycholate for solubilization.
SOLUBILITY:
Soluble in water (20mg/ml), DMSO or dimethyl formamide (30mg/ml).
ACTIVITY:
Potency is 1017µg/mg.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Antibiotic. Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Effective against yeasts and molds.
Product Specific Literature References
Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells:
J. Medoff, et al.; Cancer Res.
35
, 2548 (1975)
Abstract
;
Full Text
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung:
C.A. Presant, et al.; Cancer Treat. Rep.
68
, 651 (1984)
Abstract
Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior:
Biophys. J.; C. Barth, et al.
64
, 92 (1993)
Abstract
Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro:
B.S. Charak, et al.; Br. J. Haematol.
88
, 693 (1994)
Abstract
Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study:
J. Tollemar, et al.; Transplantation
59
, 45 (1995)
Abstract
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