ALEXIS Biochemicals: Gilvocarcin V

ALX-380-113

Revised 16-Jun-08

Gilvocarcin V
SYNONYMS	Anandimycin A Toromycin B 21085 Antibiotic 1072B
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Other Antibiotics - DNA Regulation / Transcription

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-113-C250		250 µg	180.00 USD
ALX-380-113-M001		1 mg	540.00 USD

Product Specification

FORMULA:	C₂₇H₂₆O₉
MW:	494.5
CAS NUMBER:	77879-90-4; 84236-01-1
RTECS:	DI2240000
SOURCE/HOST:	Isolated from Streptomyces sp.
PURITY:	≥98% (HPLC)
APPEARANCE:	Yellow solid.
SOLUBILITY:	Soluble in DMSO.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stock solutions are stable for at least 3 months when stored at -20°C.
HANDLING:	Protect from light also when in solution.
HAZARD:	HARMFUL.

Product Description

Antibiotic. Cytotoxic against Gram-positive bacteria. Mediates a unique cross-linking reaction between DNA and histidine H3. Weakly active against Gram-negative bacteria, fungi and tumors. Antineoplastic and photosensitizing compound.

Product Specific Literature References

Gilvocarcins, new antitumor antibiotics. 1. Taxonomy, fermentation, isolation and biological activities: H. Nakano, et al.; J. Antibiot. (Tokyo) 34, 266 (1981) Abstract
Activation of antitumor agent gilvocarcins by visible light: R.K. Elespuru and S.K. Gonda; Science 223, 69 (1984) Abstract
Photosensitized DNA breaks and DNA-to-protein crosslinks induced in human cells by antitumor agent gilvocarcin V: M.J. Peak, et al.; Chem. Biol. Interact. 67, 267 (1988) Abstract
Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico & B. H. Long; Eur. J. Cancer 29A, 1985 (1993) Abstract
Photophysical properties of gilvocarcins V and M and their binding constant to calf thymus DNA: R. Oyola, et al.; Photochem. Photobiol. 65, 802 (1997) Abstract
Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts: A. Matsumoto and P.C. Hanawalt; Cancer Res. 60, 3921 (2000) Abstract; Full Text

Further Categories Containing This Product:

Antibiotics - Antifungal • Antitumor Agents (DNA Interaction & Gene Regulation) • Antitumor Antibiotics

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