© 2008 Alexis Corporation
ALX-522-128
Revised 27-Mar-08
IL-1F6 (human) (recombinant)
SYNONYMS
Interleukin-1 Family Member 6 (human) (recombinant)
IL-1ε (human) (recombinant)
Interleukin-1ε (human) (recombinant)
PRODUCT LINE
Chemokines & Cytokines
PRODUCT CATEGORY
Interleukins
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-522-128-C050
50 µg
320.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
MW:
~16kDa (SDS-PAGE)
SOURCE/HOST:
Produced in
E. coli
(aa 1-158).
CONCENTRATION:
1mg/ml after reconstitution.
PURITY:
≥95% (SDS-PAGE)
FORMULATION:
Lyophilized. Contains PBS.
ENDOTOXIN CONTENT:
<0.1EU/µg purified protein (LAL test; Bio Whittaker).
RECONSTITUTION:
Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum.
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 6 months after receipt when stored at -20°C.
HANDLING:
After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
General Information
IL-1F5, F6, F8 and F9 are new members of the family of IL-1 (IL-1α/β, IL-18, IL-33). IL-1F6, IL-1F8 and IL-1F9 activate the NF-κB and MAPK pathways through the IL-Rrp2 and IL-1RAcP receptor complex leading to the production of IL-6 and IL-8. Agonistic activation of the IL-1F6, F8 and F9 is counterbalanced by the inhibitory activity of IL-1F5. These interleukins are mainly expressed in skin keratinocytes and internal epithelial tissues exposed to pathogenic bacteria suggesting a role in immune signalling and inflammation. IL-F5, F6 and F9 as well as the receptor IL-1Rrp2 are increased in psoriasis.
BACKGROUND/TECHNICAL INFORMATION
Swiss-Prot link Q9UHA7:
Interleukin-1 Family Member 6 (human)
MANUFACTURER
Manufactured by Apotech Corporation.
General Literature References
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs:
J.E. Towne, et al.; J. Biol. Chem.
279
, 13677 (2004)
Abstract
;
Full Text
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins
© 2008 ALEXIS Corporation,
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