© 2008 Alexis Corporation
ALX-270-442
Revised 06-Oct-08
CDK1/2 Inhibitor III
SYNONYMS
5-Amino-3-((4-(aminosulfonyl)phenyl)amino)-N-(2,6-difluorophenyl)-1
H
-1,2,4-triazole-1-carbothioamide
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-442-M001
1 mg
118.00 USD
Product Specification
FORMULA:
C
15
H
13
F
2
N
7
O
2
S
2
MW:
425.4
CAS NUMBER:
443798-55-8
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in DMSO (10mg/ml).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stock solutions are stable for up to 6 months when stored at -20°C.
HANDLING:
Protect from light.
HAZARD:
HARMFUL.
IDENTITY:
Identity determined by NMR.
Product Description
Cell permeable triazolo-diamine compound that displays anti-proliferative properties in various human cancer cells (IC
50
=20nM, 35nM and 92nM in HCT-116, HeLa, and A375 cells). Acts as a highly potent, ATP-competitive inhibitor of CDK1/cyclin B and CDK2/cyclin A (IC
50
=600pM and 500pM) with selectivity over VEGF-R2 and GSK-3β (IC
50
=32nM and 140nM).
Product Specific Literature References
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities:
R. Lin, et al.; J. Med. Chem.
48
, 4208 (2005)
Abstract
Further Categories Containing This Product:
Tyrosine Kinase Inhibitors
•
GSK-3 Inhibitors
•
Antitumor Agents (Anti-proliferative)
•
VEGFs & VEGF-Rs Other Products
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