ALEXIS Biochemicals: Galanin Like Peptide [GALP] (1-60) (pig)

ALX-157-020

Revised 03-Mar-05

Galanin Like Peptide [GALP] (1-60) (pig)
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	Galanin & Galanin Receptor / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-157-020-MC01		0.1 mg	490.00 USD

Product Specification

SEQUENCE:	H-Ala-Pro-Val-His-Arg-Gly-Arg-Gly-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Val-Leu-His-Pro-Pro-Ser-Arg-Ala-Glu-Gly-Gly-Gly-Lys-Gly-Lys-Thr-Ala-Leu-Gly-Ile-Leu-Asp-Leu-Trp-Lys-Ala-Ile-Asp-Gly-Leu-Pro-Tyr-Pro-Gln-Ser-Gln-Leu-Ala-Ser-OH
FORMULA:	C₂₈₁H₄₄₃N₈₁O₇₈
MW:	6204.1
CAS NUMBER:	245114-96-9
SOURCE/HOST:	Isolated from pig hypothalamus.
PURITY:	≥95%
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

GALP is a 60 amino acid peptide that, unlike galanin, has a non-amidated C-terminus. GALP (aa 9-21) is identical to the biologically active N-terminal (aa 1-13) portion of galanin. Receptor binding studies revealed that GALP has a high affinity for the galanin receptor 2 (IC₅₀=0.24nM) and a lower affinity for the galanin receptor 1 (IC₅₀=0.48nM). GALP is therefore an endogenous ligand that preferentially binds to galanin receptor 2, whereas galanin is relatively non-selective.

Product Specific Literature References

Isolation and cDNA cloning of a novel galanin-like peptide (GALP) from porcine hypothalamus: T. Ohtaki, et al.; J. Biol. Chem. 274, 37041 (1999) Abstract; Full Text
Galanin-like peptide (GALP) is a target for regulation by leptin in the hypothalamus of the rat: A. Jureus, et al.; Endocrinology 141, 2703 (2000) Abstract; Full Text
Galanin-like peptide (GALP) mRNA expression is restricted to arcuate nucleus of hypothalamus in adult male rat brain: J.A. Larm & A.L. Gundlach; Neuroendocrinology 72, 67 (2000) Abstract

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