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ALX-270-398 Revised 06-Feb-05
PNU 112455A . hydrochloride
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SYNONYMS N4-(6-Aminopyrimidin-4-yl)-sulfanilamide . HCl
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-398-M001   1 mg 34.00 USD Add To Cart
ALX-270-398-M005   5 mg 135.00 USD Add To Cart
Product Specification
FORMULA: C10H11N5O2S . HCl
MW: 265.3 . 36.5
PURITY: ≥95%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in DMSO or water.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
HANDLING: Protect from light and moisture. Packaged under inert gas. Hygroscopic.

Product Description
Selective and ATP-competitive inhibitor of CDK2/cyclin E  (Ki=2µM) and CDK5/p25 (Ki=2µM). Binds to the ATP-binding pocket of CDK2. Does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100µM.
Product Specific Literature References
The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism: P.M. Clare, et al.; J. Biol. Chem. 276, 48292 (2001) Abstract; Full Text
 
 
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