ALEXIS Biochemicals: Nimesulide

ALX-270-193

Revised 04-Mar-05

Nimesulide
SYNONYMS	N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	Non-Steroidal Anti-Inflammatory Drugs [NSAIDS]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-193-G005		5 g	80.00 USD

Product Specification

FORMULA:	C₁₃H₁₂N₂O₅S
MW:	308.3
CAS NUMBER:	51803-78-2
MERCK INDEX:	14: 6548
PURITY:	≥99%
APPEARANCE:	Light tan crystals.
SOLUBILITY:	Soluble in 100% ethanol, methanol, DMSO or acetonitrile. Ethanol is most commonly used for stock solutions, but solubility is only about 4mg/ml.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Selective inhibitor of cyclooxygenase 2 (COX-2). Platelet aggregation inhibitor.

Product Specific Literature References

Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system: J. Barnett, et al.; Biochim. Biophys. Acta 1209, 130 (1994) Abstract
A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2): R. Huff, et al.; Inflamm. Res. 44, S145 (1995) Abstract
Purification and characterization of prostaglandin H synthase-2 from sheep placental cotyledons: J.L. Johnson, et al.; Arch. Biochem. Biophys. 324, 26 (1995) Abstract

Further Categories Containing This Product:

Antitumor Agents (Enzyme Inhibitors) • Antitumor Agents (Apoptosis Inducers) • COX Inhibitors

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