© 2008 Alexis Corporation
ALX-380-108
Revised 03-Apr-08
Atpenin A5
SYNONYMS
3-[(2
S
,4
S
,5
R
)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1
H
)-pyridinone
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Antifungal
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-108-C250
250 µg
90.00 USD
Product Specification
FORMULA:
C
15
H
21
Cl
2
NO
5
MW:
366.2
CAS NUMBER:
119509-24-9
RTECS:
CJ8800000
SOURCE/HOST:
Produced by
Penicillium
sp.
PURITY:
≥85% (HPLC)
APPEARANCE:
Colorless oil.
SOLUBILITY:
Soluble in DMSO, methanol or 100% ethanol; insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
Product Description
Antibiotic. Potent and specific inhibitor of mitochondrial complex II (succinate-ubiquinone oxidoreductase).
Product Specific Literature References
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties:
S. Omura, et al.; J. Antibiot.
41
, 1769 (1988)
Abstract
The structures of atpenins A4, A5 and B, new antifungal antibiotics produced by Penicillium sp:
H. Kumagai, et al.; J. Antibiot.
43
, 1553 (1990)
Abstract
Mechanism of action of atpenin B on Raji cells:
K. Oshino, et al.; J. Antibiot.
43
, 1064 (1990)
Abstract
Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase):
H. Miyadera, et al.; PNAS
100
, 473 (2003)
Abstract
Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): a mechanism of electron transfer and proton conduction during ubiquinone reduction:
R. Horsefield, et al.; J. Biol. Chem.
281
, 7309 (2006)
Abstract
;
Full Text
General Information
MANUFACTURER
Fungal strain courtesy of the Kitasato Institute, Tokyo.
Further Categories Containing This Product:
Respiratory Chain Other Products
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