ALEXIS Biochemicals: JM 34

ALX-270-236

Revised 04-Feb-05

JM 34
SYNONYMS	N-(4,6-Dimethylpyridin-2-yl)furane-2-carboxamide
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	TNF-alpha & TNF Receptors Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-236-M010		10 mg	60.00 USD

Product Specification

FORMULA:	C₁₂H₁₂N₂O₂
MW:	216.2
PURITY:	≥99%
APPEARANCE:	White solid.
SOLUBILITY:	Soluble in DMSO or 100% ethanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
USE/STABILITY:	For biological studies, solubilize as a maleate salt just before use.
HANDLING:	Keep under inert gas. Protect from light.

Product Description

Anti-inflammatory pyridinylamide that inhibits TNF-α production, probably by interacting with a protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation. No inhibition of PKC activity in vitro. May serve as an alternative to classical cyclooxygenase (COX) inhibitors in TNF-α pathogenesis.

Product Specific Literature References

New antiinflammatory compounds that inhibit tumor necrosis factor production: probable interaction with protein kinase C activation: F. Lang, et al.; J. Pharmacol. Exp. Ther. 275, 171 (1995) Abstract
An anti-inflammatory benzamide derivative inhibits the protein kinase C (PKC)-dependent pathway of ERK2 phosphorylation in murine macrophages: L. Vernhet, et al.; J. Pharmacol. Exp. Ther. 283, 358 (1997) Abstract; Full Text

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