© 2008 Alexis Corporation
ALX-270-056
Revised 18-Jan-08
Bisindolylmaleimide VIII . acetate
SYNONYMS
Ro 31-7549 . acetate
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
PKC Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-056-M001
1 mg
45.00 USD
ALX-270-056-M005
5 mg
150.00 USD
Product Specification
FORMULA:
C
24
H
22
N
4
O
2
. CH
3
COOH
MW:
398.5 . 60.1
CAS NUMBER:
138516-31-1
PURITY:
≥98%
APPEARANCE:
Red powder.
SOLUBILITY:
Soluble in DMSO, methanol or water; slightly soluble in 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
Product Description
Selective inhibitor of protein kinase C (PKC). Enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.
Product Specific Literature References
Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases
:
T. Zhou, et al.; Nat. Med.
5
, 42 (1999)
Abstract
Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways
:
T. Ohtsuka & T. Zhou; J. Biol. Chem.
277
, 29294 (2002)
Abstract
;
Full Text
Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors:
D. Brehmer, et al.; Mol. Cell Proteomics
3
, 490 (2004)
Abstract
;
Full Text
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