ALEXIS Biochemicals: Ansatrienin A

ALX-380-203

Revised 27-Jun-08

Ansatrienin A
SYNONYMS	Mycotrienin I T 23I
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antitumor Antibiotics

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-203-M001		1 mg	170.00 USD

Product Specification

FORMULA:	C₃₆H₄₈N₂O₈
MW:	636.8
CAS NUMBER:	82189-03-5
RTECS:	AY4553220
SOURCE/HOST:	Isolated from Streptomyces collinus.
PURITY:	≥97% (HPLC)
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.
IDENTITY:	Identity determined by ¹H-NMR.

Product Description

Antitumor antibiotic, closely related to the cytotrienins. Significantly potentiates the action of several clinical antitumor agents. Inhibits osteoclastic bone resorption.

Product Specific Literature References

Mycotrienin, a new polyene antibiotic isolated from Streptomyces: C. Coronelli, et al.; J. Antibiot. (Tokyo) 20, 329 (1967) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. I. Taxonomy, fermentation, isolation and properties of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1460 (1982) Abstract
Studies on mycotrienin antibiotics, a novel class of ansamycins. II. Structure elucidation and biosynthesis of mycotrienins I and II: M. Sugita, et al.; J. Antibiot. (Tokyo) 35, 1467 (1982) Abstract
Potentiation of mitomycin C, 6-mercaptopurine, bleomycin, cis-diamminedichloroplatinum and 5-fluorouracil by mycotrienins and mycotrienols: M. Kuwano, et al.; Gann. 74, 759 (1983) Abstract
Mycotrienins. A new class of potent inhibitors of osteoclastic bone resorption: D. Feuerbach, et al.; J. Biol. Chem. 270, 25949 (1995) Abstract; Full Text

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