ALEXIS Biochemicals: Monoclonal Antibody to ILEI (Delphy-1)

ALX-804-857

Revised 18-Jun-08

Monoclonal Antibody to ILEI (Delphy-1)
SYNONYMS	anti-Interleukin-like EMT Inducer MAb (Delphy-1) anti-FAM3C MAb (Delphy-1)
PRODUCT LINE	Chemokines & Cytokines
PRODUCT CATEGORY	Chemokines & Cytokines Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-857-C100		100 µg	360.00 USD
ALX-804-857B-C100	Biotin	100 µg	395.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
CLONE:	Delphy-1
ISOTYPE:	Mouse IgG2a
SOURCE/HOST:	Purified from concentrated hybridoma tissue culture supernatant.
CONCENTRATION:	1mg/ml
PURITY:	≥95% (SDS-PAGE)
PURITY DETAIL:	Protein G-affinity purified.
FORMULATION:	Liquid. In PBS containing 0.02% sodium azide.
IMMUNOGEN:	Recombinant human ILEI (aa 42-227).
SPECIFICITY:	Recognizes human and mouse ILEI.
APPLICATION:	ELISA Immunoprecipitation (1:100) Western Blot (1:1’000)
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored as recommended.
HANDLING:	For long term storage keep unconjugated antibody at -20°C. Avoid freeze/thaw cycles. Keep ATTO, Biotin- and FITC-conjugated formats at +4°C. Do not freeze. Protect from light.

General Information

In 2006, T. Waerner, et al. characterized ILEI as a key player in both epithelial to mesenchymal transition and late-stage carcinoma progression. EMT is a process that involves changes in gene expression, cytoskeleton organization, cell adhesion, and extracellular matrix composition. This process is important during tissue formation and organogenesis, but also during cancer progression, metastasis and chronic inflammation. ILEI is overexpressed and/or altered in intracellular localization in multiple human tumors, an event strongly correlated to invasion/EMT, metastasis formation, and survival in human colon and breast cancer.

MANUFACTURER

Manufactured by Apotech Corporation.

General Literature References

Cloning, expression, and initial characterization of a novel cytokine-like gene family: Y. Zhu, et al.; Genomics 80, 144 (2002) Abstract
ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells: T. Waerner, et al.; Cancer Cell 10, 227 (2006) Abstract

Further Categories Containing This Product:

Cancer Other Products • Transforming Growth Factor beta [TGFbeta] & Receptors / Related Products • Monoclonal Antibodies