ALEXIS Biochemicals: Leptomycin B

ALX-380-100

Revised 14-Mar-08

Leptomycin B
SYNONYMS	LMB
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - Antifungal

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-100-C100		100 µg	95.00 USD

Product Specification

FORMULA:	C₃₃H₄₈O₆
MW:	540.7
CAS NUMBER:	87081-35-4
SOURCE/HOST:	Isolated from Streptomyces sp.
CONCENTRATION:	0.2mg/ml
PURITY:	≥98% (HPLC)
FORMULATION:	Liquid. In 100% ethanol.
SOLUBILITY:	Soluble in methanol or 100% ethanol; insoluble in water.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light. Packaged under inert gas.
HAZARD:	TOXIC. FLAMMABLE.

Product Description

Antifungal antibiotic that acts as an inhibitor of nuclear export by interacting with CRM1/exportin-1. Inhibits nucleo-cytoplasmic translocation of molecules such as the HIV-1 Rev protein and Rev-dependent export of mRNA. Other proteins that are influenced by leptomycin B are actin, c-Abl, cyclin B1, MDM2/p53, Iκb, MPF and PKA.

Product Specific Literature References

Leptomycins A and B, new antifungal antibiotics. I. Taxonomy of the producing strain and their fermentation, purification and characterization: T. Hamamoto, et al.; J. Antibiot. (Tokyo) 36, 639 (1983) Abstract
Ratjadone and leptomycin B block CRM1-dependent nuclear export by identical mechanisms: T. Meissner, et al.; FEBS Lett. 576, 27 (2004) Abstract

General Information

BACKGROUND/TECHNICAL INFORMATION

Please also see our Product Flyer "LEPTOMYCIN A+B, Inhibitors of Nuclear-Cytoplasmic Transport".

Further Categories Containing This Product:

CDK & Cyclin Inhibitors • Nuclear Envelope & Nuclear Transport • Antibiotics for Cell Cycle Research

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