ALEXIS Biochemicals: ω-Conotoxin GVIA

ALX-630-055

Revised 10-Oct-08

ω-Conotoxin GVIA
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-055-C500		500 µg	790.00 USD

Product Specification

SEQUENCE:	H-Cys-Lys-Ser-Hyp-Gly-Ser-Ser-Cys-Ser-Hyp-Thr-Ser-Tyr-Asn-Cys-Cys-Arg-Ser-Cys-Asn-Hyp-Tyr-Thr-Lys-Arg-Cys-Tyr-NH₂ (Disulfide bonds between Cys¹-Cys¹⁶, Cys⁸-Cys¹⁹and Cys¹⁵-Cys²⁶)
FORMULA:	C₁₂₀H₁₈₂N₃₈O₄₃S₆
MW:	3037.3
CAS NUMBER:	106375-28-4
SOURCE/HOST:	Synthetic. Originally isolated from Conus geographus.
QUANTITY:
CONCENTRATION:	0.1mM after reconstitution.
PURITY:	≥97%
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water.
RECONSTITUTION:	Do not remove the cap. Inject distilled water into the vial using a calibrated syringe. Dissolve all contents thoroughly.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 1 year after receipt when stored at -20°C. The aqueous solution is stable for a few weeks when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
HAZARD:	VERY TOXIC. POTENT NEUROTOXIN.

Product Description

Neurotoxin. Potent and selective blocker of neuronal N-type, voltage-dependent Ca²⁺channels. Not for sale in U.S.A.

Product Specific Literature References

Peptide neurotoxins from fish-hunting cone snails: B.M. Olivera, et al.; Science 230, 1338 (1985) Abstract
Characterization of the omega-conotoxin target. Evidence for tissue-specific heterogeneity in calcium channel types: L.J. Cruz, et al.; Biochemistry 26, 820 (1987) Abstract
Presynaptic Ca-antagonist omega-conotoxin irreversibly blocks N-type Ca-channels in chick sensory neurons: H. Kasai, et al.; Neurosci. Res. 4, 228 (1987) Abstract
Omega-conotoxin: direct and persistent blockade of specific types of calcium channels in neurons but not muscle: E.W. McCleskey, et al.; PNAS 84, 4327 (1987) Abstract
Omega-conotoxin-sensitive voltage-operated calcium channels in vertebrate cells: E. Sher & F. Clementi; Neuroscience 42, 301 (1991) Abstract
omega-Conotoxin GVIA receptors of Discopyge electric organ. Characterization of omega-conotoxin binding to the nicotinic acetylcholine receptor: W.A. Horne, et al.; J. Biol. Chem. 266, 13719 (1991) Abstract; Full Text
Conotoxins: B.M. Olivera, et al.; J. Biol. Chem. 266, 22067 (1991), (Minireview) Abstract; Full Text
Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis: J.H. Davis, et al.; Biochemistry 32, 7396 (1993) Abstract
Preparation and characterization of biotinylated analogs of the calcium channel blocker omega-conotoxin: O.T. Jones & A.P. So; Anal. Biochem. 214, 227 (1993), (Biotinylation) Abstract
Structural determinants of the blockade of N-type calcium channels by a peptide neurotoxin: P.T. Ellinor, et al.; Nature 372, 272 (1994) Abstract
Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins: B.M. Olivera, et al.; Annu. Rev. Biochem. 63, 823 (1994), (Review) Abstract
Exocytotic Ca2+ channels in mammalian central neurons: K. Dunlap, et al.; TINS 18, 89 (1995) Abstract
Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels: K.J. Nielsen, et al.; J. Mol. Recognit. 13, 55 (2000), (Review) Abstract
Rapid and reversible block of N-type calcium channels (CaV 2.2) by omega-conotoxin GVIA in the absence of divalent cations: H. Liang & K. S. Elmslie; J. Neurosci. 22, 8884 (2002) Abstract

Further Categories Containing This Product:

Ca2+ Channels (N-type) • Peptides

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