ALEXIS Biochemicals: CTRP7 Detection Set [For ELISA Application]

APO-54N-023

Revised 22-Oct-07

CTRP7 Detection Set [For ELISA Application]
SYNONYMS	C1q Tumor Necrosis Factor-α-related Protein 7 Detection Set [For ELISA Application] C1qTNF7 Detection Set [For ELISA Application]
PRODUCT LINE	Obesity & Adipokines
PRODUCT CATEGORY	C1q Tumor Necrosis Factor-alpha-related Proteins [CTRPs]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
APO-54N-023-KI01		1 Set	560.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse
SENSITIVITY:	0.1ng/ml (range 0 to 10ng/ml).
QUANTITY:	For 5x96 wells.
KIT/SET CONTAINS:	1 vial Standard (lyophilized) (STD). 1 vial Coating Antibody (COAT). 1 vial Detection Antibody (DET).
APPLICATION:	For the quantitative determination of human and mouse CTRP7 from biological fluids (serum and cell culture supernatant).
SHIPPING:	SHIPPED ON BLUE ICE
SHORT TERM STORAGE:	+4°C
LONG TERM STORAGE:	-20°C
HANDLING:	Avoid freeze/thaw cycles.

General Information

Adipose tissue functions as storage of energy and plays an active role in monitoring and controlling whole-body metabolism by secreting a number of proinflammatory adipokines, (such as leptin, resistin, tumor necrosis factor-α and interleukin-6), as well as one anti-inflammatory adipokine, adiponectin. Adiponectin is involved in controlling the whole-body metabolism, particularly by increasing insulin sensitivity in muscle and liver, and by increasing fatty acid oxidation in muscle [1]. Recently, a new highly conserved family of adiponectin paralogs designated as C1q/Tumor Necrosis Factor-α-Related Proteins (CTRPs) 1-7, has been described in mouse and human [2-5]. This family of proteins exhibits similar structural and biological properties to adiponectin. The CTRPs, unlike adiponectin whose expression is restricted to adipose tissue, are widely expressed by many different adult tissues. Like adiponectin, CTRP2 rapidly induces acetyl-CoA carboxylase, and mitogen-activated protein kinase phosphorylation in C2C12 myotubes, which resulted in increased glycogen accumulation and fatty acid oxidation, and CTRP7 (as well as CTRPs 1, 2 and 3) induces AMP-activated protein kinase phosphorylation. The activity of the CTRPs suggests that some members of the CTRP family of proteins could substitute for adiponectin function in vivo.
BACKGROUND/TECHNICAL INFORMATION	Swiss-Prot link Q8BVD7: CTRP7 (mouse) Swiss-Prot link Q9BXJ2: CTRP7 (human)
MANUFACTURER	Manufactured by Apotech Corporation.

General Literature References

[1] Adipose tissue, adipokines, and inflammation: G. Fantuzzi; J. Allergy Clin. Immunol. 115, 911 (2005) Abstract
[2] A family of Acrp30/adiponectin structural and functional paralogs: G.W. Wong, et al.; PNAS 101, 10302 (2004) Abstract
[3] C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that inhibits collagen-induced platelet aggregation by blocking VWF binding to collagen: G. Lasser, et al.; Blood 107, 423 (2006) Abstract
[4] Cartducin, a paralog of Acrp30/adiponectin, is induced during chondrogenic differentiation and promotes proliferation of chondrogenic precursors and chondrocytes: T. Maeda, et al.; J. Cell Physiol. 206, 537 (2006) Abstract
[5] The adiponectin paralog CORS-26 has anti-inflammatory properties and is produced by human monocytic cells: J. Weigert, et al.; FEBS Lett. 579, 5565 (2005) Abstract

ALX-210-924	Polyclonal Antibody to CTRP7 (AT103)
ALX-804-835	Monoclonal Antibody to CTRP7 (Anna-1)