ALEXIS Biochemicals: Amphotericin B

ALX-380-280

Revised 08-Apr-08

Amphotericin B
SYNONYMS	Fungizone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics Other Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-280-M250		250 mg	65.00 USD

Product Specification

FORMULA:	C₄₇H₇₃NO₁₇
MW:	924.1
CAS NUMBER:	1397-89-3
MERCK INDEX:	14: 585
RTECS:	BU2625000
SOURCE/HOST:	Isolated from Streptomyces sp.
APPEARANCE:	Yellow to orange powder.
PURITY DETAIL:	Contains 50% sodium deoxycholate for solubilization.
SOLUBILITY:	Soluble in water (20mg/ml), DMSO or dimethyl formamide (30mg/ml).
ACTIVITY:	Potency is 1017µg/mg.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Antibiotic. Interferes with fungal membrane permeability by forming channels in the membranes and causing small molecules to leak out. Effective against yeasts and molds.

Product Specific Literature References

Amphotericin B-induced sensitivity to actinomycin D in drug-resistant Hela cells: J. Medoff, et al.; Cancer Res. 35, 2548 (1975) Abstract; Full Text
Effects of amphotericin B with combination chemotherapy on response rates and on survival in non-small cell carcinoma of the lung: C.A. Presant, et al.; Cancer Treat. Rep. 68, 651 (1984) Abstract
Inactivation by ionizing radiation of ion channels formed by polyene antibiotics amphotericin B and nystatin in lipid membranes: an inverse dose-rate behavior: Biophys. J.; C. Barth, et al. 64, 92 (1993) Abstract
Protective effect of granulocyte-colony stimulating factor against amphotericin B-induced myelosuppression in vitro: B.S. Charak, et al.; Br. J. Haematol. 88, 693 (1994) Abstract
Liposomal amphotericin B prevents invasive fungal infections in liver transplant recipients. A randomized, placebo-controlled study: J. Tollemar, et al.; Transplantation 59, 45 (1995) Abstract

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