ALEXIS Biochemicals: Lavendustin C methyl ester

ALX-350-084

Revised 07-Apr-08

Lavendustin C methyl ester
SYNONYMS	Compound 5 methyl ester 5-Amino-N-(2,5-dihydroxybenzyl)methyl salicylate
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-084-M001		1 mg	50.00 USD
ALX-350-084-M005		5 mg	200.00 USD

Product Specification

FORMULA:	C₁₅H₁₅NO₅
MW:	289.3
SOURCE/HOST:	Synthetic.
PURITY:	≥97%
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in DMSO or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Inhibitor of EGFR tyrosine kinase with improved bioavailability over lavendustin C (Prod. No. ALX-270-066).

Product Specific Literature References

Synthesis and structure-activity studies of a series of [(hydroxybenzyl)amino]salicylates as inhibitors of EGF receptor- associated tyrosine kinase activity: H. Chen, et al.; J. Med. Chem. 36, 4094 (1993) Abstract
Structure-activity relationships in a series of 5-[(2,5- dihydroxybenzyl)amino]salicylate inhibitors of EGF-receptor-associated tyrosine kinase: importance of additional hydrophobic aromatic interactions: H. Chen, et al.; J. Med. Chem. 37, 845 (1994) Abstract