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ALX-380-012 Revised 16-Jun-08
Cytochalasin B
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SYNONYMS Phomin
PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics for Cytoskeletal Research
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-012-M001   1 mg 35.00 USD Add To Cart
ALX-380-012-M005   5 mg 90.00 USD Add To Cart
ALX-380-012-M025   25 mg 380.00 USD Add To Cart
Product Specification
FORMULA: C29H37NO5
MW: 479.6
CAS NUMBER: 14930-96-2
MERCK INDEX: 14: 2790
SOURCE/HOST: Isolated from Drechslera dematoidea.
PURITY: ≥98%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Antibiotic. Cell permeable mycotoxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
Product Specific Literature References
Cytochalasin B: effects on cell morphology, cell adhesion, and mucopolysaccharide synthesis (cultured cells-contractile microfilaments-glycoproteins-embryonic cells-sorting-out): J.W. Sanger & H. Holtzer; PNAS 69, 253 (1972) Abstract
Cytochalasin B: inhibition of glucose and glucosamine transport: R.D. Ebstensen & P.G. Plagemann; PNAS 69, 1430 (1972) Abstract
Effects of cytochalasin B on endocytosis and exocytosis: P. Davies & A.C. Allison; Front. Biol. 46, 143 (1978), Review Abstract
Effect of cytochalasin B on glucose uptake, utilization, oxidation and insulinotropic action in tumoral insulin-producing cells: W.J. Malaisse, et al.; Cell Biochem. Funct. 5, 183 (1987) Abstract
Apoptosis induced by adenosine in human leukemia HL-60 cells: Y. Tanaka, et al.; Exp. Cell Res. 213, 242 (1994) Abstract
Cytochalasin B may shorten actin filaments by a mechanism independent of barbed end capping: P.A. Theodoropoulos, et al.; Biochem. Pharmacol. 47, 1875 (1994) Abstract
The inhibition of GLUT1 glucose transport and cytochalasin B binding activity by tricyclic antidepressants: H.B. Pinkofsky, et al.; Life Sci. 66, 271 (2000) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Antithrombotic Agents / Platelet Aggregation Inhibitors / Related Products • Microtubule Modulators • Actin / Related Products • Alkaloids
 
 
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