ALEXIS Biochemicals: Monoclonal Antibody to TRAP5 (human) (TRAP-01)

ALX-804-533

Revised 20-Feb-07

Monoclonal Antibody to TRAP5 (human) (TRAP-01)
SYNONYMS	anti-Tartrate-resistant Acid Phosphatase 5 (human) MAb (TRAP-01) anti-TRACP (human) MAb (TRAP-01)
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	TRAP5 [TRACP]

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-533-C100		100 µg	508.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human
CLONE:	TRAP-01
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml after reconstitution.
PURITY DETAIL:	Protein G-affinity purified. Sterile filtered.
FORMULATION:	Lyophilized from PBS, pH 7.4.
RECONSTITUTION:	Reconstitute with 100µl of distilled water. Activity is not affected by slight turbidity. Clarify by centrifugation.
IMMUNOGEN:	Recombinant human TRAP5 (tartrate-resistant acid phosphatase 5).
SPECIFICITY:	Recognizes human TRAP5.
APPLICATION:	ELISA ImmunoCapture Enzyme-Activity Assay
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C.

Product Specific Literature References

[1] Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen: J.J. Stepan, et al.; BBRC 165, 1027 (1989) Abstract
[2] Tartrate-resistant acid phosphatase 5b: a novel serum marker of bone resorption: J.M. Halleen, et al.; J. Bone Miner. Res 15, 1337 (2000) Abstract
[3] Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity: A.J. Janckila, et al.; Clin. Chem. 47, 74 (2001) Abstract
[4] Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption: R.A. Hannon, et al.; Bone 34, 187 (2004) Abstract
[5] TRACP as an osteopontin phosphatase: G. Andersson, et al.; J. Bone Miner. Res 18, 1912 (2003) Abstract

General Information

TRAP5b is claimed to be a specific marker of bone resorption [2-4]. Both osteopontin and bone sialoprotein are colocalized with TRAP5 in the resorption lacuna of osteoclasts and dephosphorylation of osteopontin impair its ability to promote adhesion as well as migration of osteoclasts in vitro [5].

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Monoclonal Antibodies

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