ALEXIS Biochemicals: Monoclonal Antibody to Cathepsin L/Procathepsin L (CPLH 3G10)

ALX-804-293

Revised 08-Feb-05

Monoclonal Antibody to Cathepsin L/Procathepsin L (CPLH 3G10)
PRODUCT LINE	Cancer
PRODUCT CATEGORY	Cathepsin Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-293-C200		200 µg	460.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Mouse Rat
CLONE:	CPLH 3G10
ISOTYPE:	Mouse IgG1
CONCENTRATION:	1mg/ml
FORMULATION:	Liquid. Protein G pruified antibody in PBS containing 0.01% thimerosal.
IMMUNOGEN:	Purified human procathepsin L.
SPECIFICITY:	Recognizes the epitope H³⁰⁴CGLATAASY³¹³ of mouse procathepsin L. Recognizes mature mouse single or two chain cathepsin L (light chain) and mouse procathepsin L. Cross-reacts with mature human single or two chain cathepsin L (light chain), human procathepsin L and rat cathepsin L (light chain). Does not cross-react with mature cathepsins B, D, H, K, S and procathepsins B, D, F, S, W.
APPLICATION:	ELISA (capture antibody) Western Blot Optimal conditions must be determined individually for each application. Dilutions given in the figures below may be used as guidelines.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	+4°C
HANDLING:	Do not freeze.

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Product Specific Literature References

Hybridoma cells producing antibodies to cathepsin L have greatly reduced potential for tumour growth: E. Weber, et al.; J. Cancer. Res. Clin. Oncol. 120, 564 (1994) Abstract
Monoclonal antibodies against cathepsin L and procathepsin L of different species: E. Weber, et al.; Hybridoma 16, 159 (1997) Abstract
Immunohistochemical and clinical evaluation of cathepsin expression in soft tissue sarcomas: P. Wurl, et al.; Virchows Arch. 430, 221 (1997) Abstract

General Information

Cathepsin L [EC 3.4.22.15] is a lysosomal endopeptidase belonging to the papain family of the closely related cysteine proteases superfamily. The enzyme is ubiquitously distributed in the lysosomes of all cells and seems to be involved in a variety of disorders in which the pathological destruction of the extracellular matrix is one of the main characteristics.

Further Categories Containing This Product:

Monoclonal Antibodies

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