© 2008 Alexis Corporation
ALX-270-204
Revised 24-Jun-08
bpV(phen)
SYNONYMS
Potassium bisperoxo (1,10-phenanthroline) oxovanadate (V)
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Oxovanadates
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-204-M005
5 mg
53.00 USD
ALX-270-204-M025
25 mg
195.00 USD
Product Specification
FORMULA:
K[VO(O
2
)
2
C
12
H
8
N
2
] . 3H
2
O
MW:
350.3 . 54.0
PURITY:
≥98% (
51
V-NMR)
APPEARANCE:
Yellow to orange powder.
SOLUBILITY:
Soluble in water (10mM).
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light.
IDENTITY:
Identity determined by MS and
51
V-NMR (D
2
O)
Product Description
Potent protein phosphotyrosine phosphatase inhibitor. Also shown to be a potent insulin receptor kinase activator; excellent insulin mimetic
in vitro
and
in vivo
.
Product Specific Literature References
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics:
B.I. Posner, et al.; J. Biol. Chem.
269
, 4596 (1994)
Abstract
;
Full Text
Selective activation of the rat hepatic endosomal insulin receptor kinase. Role for the endosome in insulin signaling:
A.P. Bevan, et al.; J. Biol. Chem.
270
, 10784 (1995)
Abstract
;
Full Text
In vivo insulin mimetic effects of pV compounds: role for tissue targeting in determining potency:
A.P. Bevan, et al.; Am. J. Physiol.
268
, E60 (1995)
Abstract
Hypoglycemic effects of peroxovanadium compounds in Sprague-Dawley and diabetic BB rats:
J.F. Yale, et al.; Diabetes
44
, 1274 (1995)
Abstract
A role for tyrosine phosphorylation in both activation and inhibition of the insulin receptor tyrosine kinase in vivo:
P.G. Drake, et al.; Endocrinology
137
, 4960 (1996)
Abstract
Phosphatidylinositol 3'-kinase and p70s6k are required for insulin but not bisperoxovanadium 1,10-phenanthroline (bpV(phen)) inhibition of insulin-like growth factor binding protein gene expression. Evidence for MEK-independent activation of mitogen-activ:
C.J. Band & B.I. Posner; J. Biol. Chem.
272
, 138 (1997)
Abstract
;
Full Text
Lipopolysaccharide down-regulates the leukotriene C4 synthase gene in the monocyte-like cell line, THP-1:
K.J. Serio, et al.; J. Immunol.
170
, 2121 (2003)
Abstract
;
Full Text
Further Categories Containing This Product:
Insulin & Insulin Receptor / Related Products
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