© 2008 Alexis Corporation
ALX-270-385
Revised 17-Jul-07
Aloisine A
SYNONYMS
RP107
7-
n
-Butyl-6-(4-hydroxyphenyl)[5
H
]pyrrolo[2,3-
b
]pyrazine
PRODUCT LINE
Cell Cycle
PRODUCT CATEGORY
CDK & Cyclin Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-385-M001
1 mg
30.00 USD
Product Specification
FORMULA:
C
16
H
17
N
3
O
MW:
267.3
PURITY:
≥95%
APPEARANCE:
Yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Cell permeable, potent, selective, reversible and ATP-competitive inhibitor of CDK1/cyclin B (IC
50
=150nM), CDK2/cyclin A (IC
50
=120nM), CDK2/cyclin E (IC
50
=400nM), CDK5/p25
(IC
50
=200nM), CDK5/p35 (IC
50
=160nM) and GSK-3α (IC
50
=500nM). Also inhibits GSK-3β (IC
50
=650nM) and c-Jun N-terminal kinase (JNK) (IC
50
~3-10µM). Poor inhibitor of CK1, CK2, CDK4/cyclin D1, MAPKK, PKA, PKG, PKCs and c-raf (IC
50
≥100µM). Blocks cell cycle in both G1 and G2 phase.
Product Specific Literature References
Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects
:
Y. Mettey, et al.; J. Med. Chem.
46
, 222 (2003)
Abstract
Further Categories Containing This Product:
Cell Cycle Blockers & Inhibitors/Related Products
GSK-3 Inhibitors
JNK [SAPK1]/Related Products
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