© 2008 Alexis Corporation
ALX-380-207
Revised 03-Apr-08
Apoptolidin
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - Apoptosis Inducers & Inhibitors
Ordering Information
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ALX-380-207-MC01
0.1 mg
290.00 USD
Product Specification
FORMULA:
C
58
H
96
O
21
MW:
1129.4
CAS NUMBER:
194874-06-1
SOURCE/HOST:
Isolated from
Amicolatopsis
sp. MST-AS5912.
PURITY:
≥95% (HPLC)
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in 100% ethanol, methanol, dimethyl formamide or DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HAZARD:
HARMFUL.
Product Description
Originally isolated from
Nocardiopsis
sp. Antibiotic. Potent and highly selective apoptosis inducer in several cancer cell lines. F
0
F
1
-ATPase inhibitor.
Product Specific Literature References
Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp:
J.W. Kim, et al.; J. Antibiot. (Tokyo)
50
, 6628 (1997)
Abstract
Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase:
A.R. Salomon, et al.; PNAS
97
, 14766 (2000)
Abstract
;
Full Text
Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase:
A.R. Salomon, et al.; Chem. Biol.
8
, 71 (2001)
Abstract
;
Full Text
Apoptolidin: induction of apoptosis by a natural product:
P.T. Daniel, et al.; Angew. Chem. Int. Ed. Engl.
45
, 872 (2006)
Abstract
Correlation of F0F1-ATPase inhibition and antiproliferative activity of apoptolidin analogues:
P.A. Wender, et al.; Org. Lett.
8
, 589 (2006)
Abstract
Further Categories Containing This Product:
Natural Products - ATPase Inhibitors
•
Antitumor Agents (Apoptosis Inducers)
•
Antitumor Antibiotics
•
Respiratory Chain Other Products
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