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ALX-801-027 Revised 15-Oct-07
Monoclonal Antibody to Breast Cancer Resistance Protein (human) (BXP-34)
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SYNONYMS anti-BCRP (human) MAb (BXP-34)
anti-MXR (human) MAb (BXP-34)
anti-ABCG2 (human) MAb (BXP-34)
anti-CD338 (human) MAb (BXP-34)
PRODUCT LINE Cancer
PRODUCT CATEGORY Breast Cancer Resistance Protein [BCRP/MXR]/Related Products
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-801-027-C125   125 µg 350.00 USD Add To Cart
ALX-801-027-C250   250 µg 630.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
CLONE: BXP-34
ISOTYPE: Mouse IgG1
CONCENTRATION: ~250µg/ml
FORMULATION: Liquid. In serum free cell culture supernatant containing 0.7% BSA and 0.1% sodium azide.
IMMUNOGEN: Mitoxanthone resistant BCRP (breast cancer resistance protein; MXR) overexpressing cell line MCF7MR.
SPECIFICITY: Recognizes an internal epitope of human BCRP. Does not cross-react with human P-glycoprotein, MRP1, MRP2 or MRP5.
APPLICATION: Flow Cytometry
Immunocytochemistry: Use 1:20-1:50 dilution on acetone fixed cytospin preparations.
Immunohistochemistry (frozen sections): Use 1:20 dilution of BXP-34 on acetone fixed frozen sections followed by incubation with rabbit anti-mouse IgG and a monoclonal mouse APAAP complex. BXP-34 cannot be used on formaldehyde-fixed paraffin-embedded human tissues and tumors.
Not recommended for Western blot.
SHIPPING: SHIPPED ON BLUE ICE
SHORT TERM STORAGE: +4°C
LONG TERM STORAGE: -20°C
Product Specific Literature References
Breast cancer resistance protein is localized at the plasma membrane in mitoxantrone- and topotecan-resistant cell lines: G.L. Scheffer, et al.; Cancer Res. 60, 2589 (2000) Abstract; Full Text
Subcellular localization and distribution of the breast cancer resistance protein transporter in normal human tissues: M. Maliepaard, et al.; Cancer Res. 61, 3458 (2001) Abstract; Full Text
Breast cancer resistance protein expression and resistance to daunorubicin in blast cells from patients with acute myeloid leukaemia: J.M. Sargent, et al.; Br. J. Haematol. 115, 257 (2001) Abstract
The role of breast cancer resistance protein in acute lymphoblastic leukemia: S.L. Plasschaert, et al.; Clin. Cancer Res. 9, 5171 (2003) Abstract
General Literature References
A multidrug resistance transporter from human MCF-7 breast cancer cells: L.A. Doyle, et al.; PNAS 95, 15665 (1998) Abstract; Full Text
Further Categories Containing This Product:
CD Antibodies • Tumor Markers • Monoclonal Antibodies
 
 
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