ALEXIS Biochemicals: MnTMPyP . pentachloride

ALX-430-070

Revised 05-Mar-08

MnTMPyP . pentachloride
SYNONYMS	Manganese (III) tetrakis (1-methyl-4-pyridyl)porphyrin . 5Cl^-
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Porphyrins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-430-070-M010		10 mg	20.00 USD
ALX-430-070-M050		50 mg	50.00 USD

Product Specification

FORMULA:	C₄₄H₃₆MnN₈Cl₅
MW:	909.0
PURITY:	≥95%
APPEARANCE:	Black crystalline powder.
SOLUBILITY:	Soluble in water or aqueous buffers (e.g. 0.1M TRIS-HCl, pH 9.0 containing 1mM EDTA (>50mg/ml) or PBS, pH 7.2 (4mg/ml)).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Prepare solutions immediately before experiments. We recommend using fresh preparations each day.

Product Description

Cell permeable SOD mimetic. Catalyzes the dismutation of O₂^- even in the presence of excess EDTA.

Product Specific Literature References

Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994) Abstract; Full Text
A cationic manganic porphyrin inhibits uptake of paraquat by Escherichia coli: S.I. Liochev & I. Fridovich; Arch. Biochem. Biophys. 321, 271 (1995) Abstract
Superoxide scavenging by Mn(II/III) tetrakis (1-methyl-4-pyridyl) porphyrin in mammalian cells: P.R. Gardner, et al.; Arch. Biochem. Biophys. 325, 20 (1996) Abstract
The ortho effect makes manganese(III) meso-tetrakis(N-methylpyridinium- 2-yl)porphyrin a powerful and potentially useful superoxide dismutase mimic: Batinic-Haberle, et al.; J. Biol. Chem. 273, 24521 (1998) Abstract; Full Text
Molecular actions of a Mn(III)Porphyrin superoxide dismutase mimetic and peroxynitrite scavenger: reaction with nitric oxide and direct inhibition of NO synthase and soluble guanylyl cyclase: S. Pfeiffer, et al.; Mol. Pharmacol. 53, 795 (1998) Abstract
SODs are involved in the regulation of ICAM-1 expression in human melanoma and endothelial cells: R. Morandini, et al.; Cell. Mol. Biol. (Noisy-le-grand) 45, 1053 (1999) Abstract
Effects of superoxide dismutase mimetics on the activity of nitric oxide in rat aorta: A. MacKenzie, et al.; Br. J. Pharmacol. 127, 1159 (1999) Abstract
Inducible nitric oxide synthase-derived superoxide contributes to hypereactivity in small mesenteric arteries from a rat model of chronic heart failure: A.A. Miller, et al.; Br. J. Pharmacol. 131, 29 (2000) Abstract

Further Categories Containing This Product:

NOS Inhibitors (NOS Induction & Enzyme Activity) • Superoxide Dismutases [SODs]/Related Products • Antioxidants, Flavonoids & Free Radical Scavengers Other Products

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