© 2008 Alexis Corporation
ALX-522-080 Revised 24-Mar-05
BAFF-R (mouse):Fc (human) (recombinant)
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SYNONYMS BR3 (mouse):Fc (human) (recombinant)
BlySR3 (mouse):Fc (human) (recombinant)
TNFRSF 13C (mouse):Fc (human) (recombinant)
CD268 (mouse):Fc (human) (recombinant)
PRODUCT LINE Chemokines & Cytokines
PRODUCT CATEGORY BAFF-R
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-522-080-C050   50 µg 365.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
MW: ~35kDa (SDS-PAGE).
SOURCE/HOST: Produced in HEK 293 cells. The extracellular domain of mouse BAFF-R (aa 2-70) is fused at the C-terminus to a linker peptide (10 aa) and the Fc portion of human IgG1.
CONCENTRATION: 1mg/ml (after reconstitution).
PURITY: ≥95% (SDS-PAGE)
FORMULATION: Lyophilized. Contains PBS.
ENDOTOXIN CONTENT: <0.1EU/µg purified protein (LAL test; BioWhittaker).
RECONSTITUTION: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
SPECIFICITY: Binds mouse and human BAFF.
BIOLOGICAL ACTIVITY: Blocks the binding of mouse and human BAFF to their BAFF-receptors, inhibiting BAFF-mediated splenocyte survival.
APPLICATION: Flow Cytometry: Detection of membrane-bound mouse and human BAFF.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: -20°C
USE/STABILITY: Stable for at least 6 months after receipt when stored at -20°C.
HANDLING: After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
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Product Specific Literature References
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004) Abstract
General Information
BAFF-R:Fc is 10-fold more efficacious than BCMA:Fc for blocking BAFF-induced B cell proliferation in vitro and for blocking BAFF-mediated survival of mouse splenic B lymphocytes in vivo. Thus BAFF-R:Fc becomes a promising therapeutic candidate as a BAFF-neutralizing compound in autoimmune disease intervention [1].
BACKGROUND/TECHNICAL INFORMATION Swiss-Prot link Q9D8D0: BAFF-R (mouse)
AfCS Siganlling Gateway link A002648: BAFF-R (mouse)
MANUFACTURER Manufactured by Apotech Corporation.
General Literature References
Comparison of soluble decoy IgG fusion proteins of BAFF-R and BCMA as antagonists for BAFF: M. Pelletier, et al.; J. Biol. Chem. 278, 33127 (2003) Abstract
BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16 467 2004 16, 467 (2004) Abstract
Further Categories Containing This Product:
Recombinant Proteins/Fusion Proteins