ALEXIS Biochemicals: Monoclonal Antibody to COX-2 (CX229)

ALX-804-112

Revised 18-Sep-07

Monoclonal Antibody to COX-2 (CX229)
SYNONYMS	anti-Cyclooxygenase-2 MAb (CX229) anti-Prostaglandin H Synthase 2 MAb (CX229)
PRODUCT LINE	Inflammation
PRODUCT CATEGORY	COX Antibodies

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-804-112-C050		50 µg	313.00 USD

Product Specification

SPECIES CROSSREACTIVITY:	Human Sheep Monkey
CLONE:	CX229
ISOTYPE:	Mouse IgG1
CONCENTRATION:	0.5mg/ml after reconstitution.
FORMULATION:	Lyophilized.
RECONSTITUTION:	Reconstitute with 100µl distilled water.
IMMUNOGEN:	Synthetic peptide corresponding to aa 580-599 (N⁵⁸⁰ASSSRSGLDDINPTVLLKE⁵⁹⁹) of human COX-2 (cyclooxygenase 2).
SPECIFICITY:	Recognizes human, monkey and sheep COX-2. Detects a band of ~72kDa by Western blot. Expected to cross-react with bovine and dog COX-2. Does not cross-react with COX-1 or with mouse, rat or rabbit COX-2.
APPLICATION:	Immunohistochemistry (1:50-1:100) Western Blot (1:1'000) Optimal conditions must be determined individually for each application.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Stable for at least 3 years when stored at -20°C.
HANDLING:	After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Product Specific Literature References

Differential measurement of constitutive (COX-1) and inducible (COX-2) cyclooxygenase expression in human umbilical vein endothelial cells using specific immunometric enzyme immunoassays: C. Créminon, et al.; Biochim. Biophys. Acta 1254, 341 (1995) Abstract
The viral protein A238L inhibits cyclooxygenase-2 expression through a nuclear factor of activated T cell-dependent transactivation pathway: A.G. Granja, et al.; J. Biol. Chem. 279, 53736 (2004) Abstract; Full Text

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Monoclonal Antibodies

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