© 2008 Alexis Corporation
ALX-270-372
Revised 08-Jul-08
2,4-Diethylpyridine dicarboxylate
SYNONYMS
2,4-DPD
2,4-Pyridinedicarboxylic acid diethyl ester
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Hypoxia-inducible Factor [HIF] / Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-372-M010
10 mg
23.00 USD
ALX-270-372-M025
25 mg
53.00 USD
ALX-270-372-M100
100 mg
177.00 USD
Product Specification
FORMULA:
C
11
H
13
NO
4
MW:
223.2
CAS NUMBER:
41438-38-4
CONCENTRATION:
50mg/ml
PURITY:
≥98%
FORMULATION:
Liquid. Solution in ethanol.
SOLUBILITY:
Soluble in 100% ethanol (50mg/ml), DMSO (20mg/ml) or dimethyl formamide (30mg/ml); slightly soluble in PBS, pH 7.2 (1mg/ml).
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Stable for at least 1 year after receipt when stored at –20°C. We do not recommend storing aqueous solutions for more than one day.
Product Description
2,4-DPD is a cell permeable, competitive inhibitor of the oxygen-sensing enzyme HIF prolyl hydroxylase (HIF-PH), which destructs HIF-1α when hydroxylated at a specific proline residue (P564). 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range. 2,4-DPD is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.
Product Specific Literature References
Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans
:
L. Friedman, et al.; PNAS
97
, 4736 (2000)
Abstract
;
Full Text
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing
:
M. Ivan, et al.; Science
292
, 464 (2001)
Abstract
Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
:
P. Jaakkola, et al.; Science
292
, 468 (2001)
Abstract
A conserved family of prolyl-4-hydroxylases that modify HIF
:
R.K. Bruick & S.L. McKnight; Science
294
, 1337 (2001)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
To change the solvent, simply evaporate the ethanol under a gentle stream of nitrogen and immediately add the solvent of choice.
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