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ALX-270-397 Revised 09-Jan-08
Olomoucine, N9-Isopropyl-
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SYNONYMS 6-Benzylamino-2-(2-hydroxyethylamino)-9-Isopropylpurine
PRODUCT LINE Cell Cycle
PRODUCT CATEGORY CDK & Cyclin Inhibitors
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-270-397-M001   1 mg 40.00 USD Add To Cart
ALX-270-397-M005   5 mg 120.00 USD Add To Cart
Product Specification
FORMULA: C17H22N6O
MW: 326.4
CAS NUMBER: 158982-15-1
PURITY: ≥98% (HPLC)
APPEARANCE: White to off-white crystalline solid.
SOLUBILITY: Soluble in DMSO or dimethyl formamide; sparingly soluble in methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: -20°C
USE/STABILITY: Stock solutions are stable for 3 months when stored at -20°C.

Product Description
Inhibitor of CDK1/cyclin B (IC50=2µM) and CDK5/p35 (IC50=3µM).
Product Specific Literature References
Inhibition of cyclin-dependent kinases by purine analogues: J. Vesely, et al.; Eur. J. Biochem. 224, 771 (1994) Abstract
Cassette dosing pharmacokinetics of a library of 2,6,9-trisubstituted purine cyclin-dependent kinase 2 inhibitors prepared by parallel synthesis: F.I. Raynaud, et al.; Mol. Cancer Ther. 3, 353 (2004) Abstract
 
 

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