© 2008 Alexis Corporation
ALX-210-116
Revised 29-Sep-08
Polyclonal Antibody to Heme Oxygenase-1
SYNONYMS
anti-HO-1 PAb
PRODUCT LINE
Oxidative Stress
PRODUCT CATEGORY
Heme Oxygenase / Related Products
Ordering Information
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Unit Price:
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ALX-210-116-R100
100 µl
379.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
Rat
Monkey
Others
SOURCE/HOST:
From rabbit.
FORMULATION:
Liquid. Neat serum diluted in PBS containing 0.05% sodium azide.
IMMUNOGEN:
Synthetic peptide corresponding to aa 1-30 (M
1
ERPQLDSMSQDL
SEALKEATKEVHIRAEN
30
) of N-terminal rat HO-1 (heme oxygenase-1).
SPECIFICITY:
Recognizes human, mouse, rat, monkey and bovine HO-1. Detects a band of ~32kDa by Western blot. Does not cross-react with HO-2.
APPLICATION:
Immunocytochemistry
Immunohistochemistry (paraffin sections (1:100))
Western Blot (1:1’000)
SHIPPING:
SHIPPED ON BLUE ICE
LONG TERM STORAGE:
-20°C
HANDLING:
Avoid freeze/thaw cycles.
Product Specific Literature References
Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease:
M.A. Smith, et al.; Am. J. Pathol.
145
, 42 (1994)
Abstract
RT-PCR assay for heme oxygenase-1 and heme oxygenase-2: a sensitive method to estimate cellular oxidative damage:
R.K. Kutty, et al.; Ann. N. Y. Acad. Sci.
738
, 427 (1994)
Abstract
Increased expression of heme oxygenase-1 in human retinal pigment epithelial cells by transforming growth factor-beta:
R.K. Kutty, et al.; J. Cell. Physiol.
159
, 371 (1994)
Abstract
Induction of heme oxygenase 1 in the retina by intense visible light: suppression by the antioxidant dimethylthiourea:
R.K. Kutty, et al.; PNAS
92
, 1177 (1995)
Abstract
Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion:
A.C. Zenclussen, et al.; Scand. J. Immunol.
55
, 560 (2002)
Abstract
Protection from abortion by heme oxygenase-1 up-regulation is associated with increased levels of Bag-1 and neuropilin-1 at the fetal-maternal interface:
A. Sollwedel, et al.; J. Immunol.
175
, 4875 (2005)
Abstract
Heme oxygenase as a therapeutic target in immunological pregnancy complications:
A.C. Zenclussen, et al.; Int. Immunopharmacol.
5
, 41 (2005)
Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION
Immunohistochemical staining of HO-1 in Alzheimer's diseased human brain with Prod. No.
ALX-210-116
results in staining of the neurofibrillary tangles, senile plaque neurites and neurophil threads.
Further Categories Containing This Product:
Polyclonal Antibodies
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