© 2008 Alexis Corporation
ALX-804-370
Revised 14-Feb-08
Monoclonal Antibody to Dnmt3a (mouse) (64B1446)
SYNONYMS
anti-DNA Methyltransferase-3a MAb (mouse) (64B1446)
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
DNA & RNA Methyl & Alkyl Transferases/Related Products
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
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ALX-804-370-C100
100 µg
293.00 USD
Product Specification
SPECIES CROSSREACTIVITY:
Mouse
CLONE:
64B1446
ISOTYPE:
Mouse IgG1
CONCENTRATION:
0.5mg/ml
PURITY DETAIL:
Protein G-affinity purified.
FORMULATION:
Liquid. In PBS containing 0.05% BSA and 0.05% sodium azide.
IMMUNOGEN:
Recombinant mouse Dnmt3a (DNA methyltransferase-3a).
SPECIFICITY:
Recognizes C-terminal epitope aa 705-908 of mouse Dnmt3a [1]. Weakly cross-reacts with human Dnmt3a.
APPLICATION:
Immunocytochemistry (5µg/ml)
Immunohistochemistry (1:400) (see [8])
Immunoprecipitation, Chromatin Immunoprecipitation (see [4])
Western Blot (2µg/ml)
SHIPPING:
SHIPPED ON BLUE ICE
SHORT TERM STORAGE:
+4°C
LONG TERM STORAGE:
-20°C
Product Images
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Product Specific Literature References
[1]
Lsh, a member of the SNF2 family, is required for genome-wide methylation
:
K. Dennis, et al.; Genes Dev.
15
, 2940 (2001)
Abstract
;
Full Text
[2]
A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation
:
T. Chen, et al.; J. Biol. Chem.
277
, 38746 (2002)
Abstract
[3]
Association of Lsh, a regulator of DNA methylation, with pericentromeric heterochromatin is dependent on intact heterochromatin:
Q. Yan, et al.; Mol. Cell. Biol.
23
, 8416 (2003)
Abstract
;
Full Text
[4]
Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer:
Y.W. Leu, et al.; Cancer Res.
64
, 8184 (2004)
Abstract
[5]
De novo DNA methyltransferases Dnmt3a and Dnmt3b primarily mediate the cytotoxic effect of 5-aza-2’-deoxycytidine:
M. Oka, et al.; Oncogene
24
, 3091 (2005)
Abstract
[6]
Myc represses transcription through recruitment of DNA methyltransferase corepressor:
C. Brenner, et al.; EMBO
24
, 336 (2005)
Abstract
[7]
Cell and stage of transformation-specific effects of folate deficiency on methionine cycle intermediates and DNA methylation in an in vitro model:
J.M. Stempak, et al.; Carcinogenesis
26
, 981 (2005)
Abstract
[8]
Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system:
J. Feng, et al.; J. Neurosci. Res.
79
, 734 (2005)
Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
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