© 2008 Alexis Corporation
ALX-290-009
Revised 02-Apr-04
α-Hydroxyfarnesylphosphonic acid
PRODUCT LINE
Signal Transduction
PRODUCT CATEGORY
Farnesylation / Isoprenylation Reagents
Ordering Information
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Format:
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Unit Price:
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ALX-290-009-M001
1 mg
160.00 USD
Product Specification
FORMULA:
C
15
H
27
O
4
P
MW:
302.4
PURITY:
≥96%
FORMULATION:
Liquid. 1mg dissolved in 500µl ethanol.
SOLUBILITY:
Soluble in DMSO or 100% ethanol.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
USE/STABILITY:
Product decomposes rapidly when not in solution. Do not evaporate to dryness.
Product Description
Potent inhibitor of farnesyltransferase in cell-free enzyme preparations (IC
50
=30nM) and in whole cells. Selectively inhibits farnesyltransferase over geranylgeranyltransferases I and II (IC
50
=35.8µM and IC
50
=67.0µM).
Product Specific Literature References
Steady-state kinetic mechanism of Ras farnesyl:protein transferase:
D.L. Pompliano, et al.; Biochemistry
31
, 3800 (1992)
Abstract
Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo:
J.B. Gibbs, et al.; J. Biol. Chem.
268
, 7617 (1993)
Abstract
;
Full Text
Inhibitors of Ras farnesyltransferases:
F. Tamanoi; TIBS
18
, 349 (1993), (Review)
Abstract
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