ALEXIS Biochemicals: Margatoxin

ALX-630-045

Revised 10-Oct-08

Margatoxin
SYNONYMS	MgTx
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-630-045-C100		100 µg	520.00 USD

Product Specification

SEQUENCE:	H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH (Disulfide bonds between Cys⁷-Cys²⁹, Cys¹³-Cys³⁴ and Cys¹⁷-Cys³⁶)
FORMULA:	C₁₇₈H₂₈₆N₅₂O₅₀S₇
MW:	4179.0
CAS NUMBER:	145808-47-5
RTECS:	YX3963700
SOURCE/HOST:	Synthetic. Originally isolated from Centruroides margaritatus.
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	HARMFUL.

Product Description

Voltage dependent K⁺channel blocker (specific for Kv1.3 channel). Inhibitor of T cell activation. Immunosuppressor.

Product Specific Literature References

Selective blockers of voltage-gated K+ channels depolarize human T lymphocytes: mechanism of the antiproliferative effect of charybdotoxin: R.J. Leonard, et al.; PNAS 89, 10094 (1992) Abstract
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels: M. Garcia-Calvo, et al.; J. Biol. Chem. 268, 18866 (1993) Abstract; Full Text
Chemical synthesis and structure-function studies of margatoxin, a potent inhibitor of voltage-dependent potassium channel in human T lymphocytes: M.A. Bednarek, et al.; Biochem. Biophys. Res. Commun. 198, 619 (1994) Abstract
[125I]margatoxin, an extraordinarily high affinity ligand for voltage-gated potassium channels in mammalian brain: H.G. Knaus, et al.; Biochemistry 34, 13627 (1995) Abstract
Margatoxin increases dopamine release in rat striatum via voltage-gated K+ channels: A. Saria, et al.; Eur. J. Pharmacol. 343, 193 (1998) Abstract
Immunosuppressive effects of a Kv1.3 inhibitor: K. Shah, et al.; Cell Immunol3 221, 100 (2003) Abstract
Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells: A. Erdogan, et al.; J. Vasc. Res. 42, 368 (2005) Abstract
Characterization of the functional properties of the voltage-gated potassium channel Kv1.3 in human CD4+ T lymphocytes: L. Hu, et al.; J. Immunol. 179, 4563 (2007) Abstract

Further Categories Containing This Product:

K+ Channel Blockers & Inhibitors • Natural Products - Immunomodulators

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