© 2008 Alexis Corporation
ALX-270-278
Revised 01-Jul-08
5-Iodo-6-amino-1,2-benzopyrone
SYNONYMS
INH
2
BP
PRODUCT LINE
DNA Regulation / Transcription
PRODUCT CATEGORY
PARP Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-270-278-M001
1 mg
25.00 USD
ALX-270-278-M005
5 mg
50.00 USD
Product Specification
FORMULA:
C
9
H
6
INO
2
MW:
287.1
CAS NUMBER:
137881-27-7
PURITY:
≥98%
APPEARANCE:
Off-white to yellow solid.
SOLUBILITY:
Soluble in DMSO.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
+4°C
HANDLING:
Protect from light. Packaged under inert gas.
Product Description
Inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
Product Specific Literature References
Reversion of malignant phenotype by 5-iodo-6-amino-1,2-benzopyrone a non-covalently binding ligand of poly(ADP-ribose) polymerase:
P.I. Bauer, et al.; Biochimie
77
, 374 (1995)
Abstract
Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development:
M. Endres, et al.; Eur. J. Pharmacol.
351
, 377 (1998)
Abstract
Poly(ADP-ribose) synthetase activation mediates increased permeability induced by peroxynitrite in Caco-2BBe cells:
M. Kennedy, et al.; Gastroenterology
114
, 510 (1998)
Abstract
Potential role of the peroxynitrate-poly(ADP-ribose) synthetase pathway in a rat model of severe hemorrhagic shock:
C. Szabó, et al.; Shock
9
, 341 (1998)
Abstract
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthase:
C. Szabó, et al.; PNAS
95
, 3867 (1998)
Abstract
;
Full Text
Crucial role of apopain in the peroxynitrite-induced apoptotic DNA fragmentation:
L. Virág, et al.; Free Radic. Biol. Med.
25
, 1075 (1998)
Abstract
Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidant-induced cell death:
L. Virág, et al.; J. Immunol.
161
, 3753 (1998)
Abstract
;
Full Text
Novel roles of nitric oxide in hemorrhagic shock:
C. Szabo & T.R. Billiar; Shock
12
, 1 (1999)
Abstract
Cancer cell selectivity of 5-iodo-6-aminobenzopyrone (INH2BP) and methyl-3,5-diiodo-4(4'-methoxyphenoxy) benzoate (DIME):
E. Kirsten & E. Kun; Int. J. Mol. Med.
5
, 279 (2000)
Abstract
Role of poly(ADP-ribose) synthetase activation in the development of experimental allergic encephalomyelitis
:
G.S. Scott, et al.; J. Neuroimmunol.
117
, 78 (2001)
Abstract
Inhibition of poly (ADP-ribose) synthetase by gene disruption or inhibition with 5-iodo-6-amino-1,2-benzopyrone protects mice from multiple-low-dose-streptozotocin-induced diabetes
:
J.G. Mabley, et al.; Br. J. Pharmacol.
133
, 909 (2001)
Abstract
Further Categories Containing This Product:
DNA Repair Other Products
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