ALEXIS Biochemicals: Luteolin

ALX-385-007

Revised 07-Apr-08

Luteolin
SYNONYMS	3',4',5,7-Tetrahydroxyflavone
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Flavonoids/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-385-007-M010		10 mg	15.00 USD
ALX-385-007-M050		50 mg	45.00 USD

Product Specification

FORMULA:	C₁₅H₁₀O₆
MW:	286.2
CAS NUMBER:	491-70-3
MERCK INDEX:	14: 5614
RTECS:	LK9275210
PURITY:	≥90%
APPEARANCE:	Yellow powder.
SOLUBILITY:	Soluble in methanol, alkaline solutions; slightly soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+20°C

Product Description

Antioxidant flavonoid. Inhibits VEGF-induced angiogenesis. Inhibitor of the catalytic activity of phosphoinositide 3-kinase (PI(3)K), whereas inhibition of PI(3)K by luteolin affects apoptosis via PI(3)K/Akt (protein kinase B; PKB) pathways and antimitotic effects via PI(3)K/p70S6K pathways. Inhibitor of fatty acid synthase (FAS). Apoptosis inducer.

Product Specific Literature References

Structure-antioxidant activity relationships of flavonoids and phenolic acids: C.A. Rice-Evans, et al.; Free Radical Biol. & Med. 20, 933 (1996), (Review) Abstract
Luteolin inhibits vascular endothelial growth factor-induced angiogenesis; inhibition of endothelial cell survival and proliferation by targeting phosphatidylinositol 3'-kinase activity: E. Bagli, et al.; Cancer Res. 64, 7936 (2004)
Dietary flavonoids: bioavailability, metabolic effects, and safety: J.A. Ross & C.M. Kasum; Annu. Rev. Nutr. 221, 19 (2002), (Review) Abstract
Pharmacological inhibitors of Fatty Acid Synthase (FASN)--catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents?: R. Lupu & J. A. Menendez; Curr. Pharm. Biotechnol. 7, 483 (2006), (Review) Abstract

Further Categories Containing This Product:

Free Radical Scavengers • Phosphoinositide 3-kinase [PI(3)K]/Related Products • Natural Products for Angiogenesis Research • Fatty Acid Synthase [FAS]/Related Products • Natural Products - Antioxidants • Natural Products - Apoptosis Inducers & Inhibitors

another CS2 website

Online Product Ordering

Clipboard [0]

Your items will be kept only for the duration of your visit.