© 2008 Alexis Corporation
ALX-804-579 Revised 18-Jun-08
Monoclonal Antibody to SEL1L (MSel1)
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SYNONYMS anti-Suppressor of lin-12-like Protein MAb (MSel1)
PRODUCT LINE Stress & Heat Shock Proteins
PRODUCT CATEGORY Endoplasmatic Reticulum Stress
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-804-579-C100   100 µg 320.00 USD Add To Cart
Product Specification
SPECIES CROSSREACTIVITY:
Human
Mouse
CLONE: MSel1
ISOTYPE: Mouse IgG1
CONCENTRATION: 1mg/ml
FORMULATION: Liquid. In 150mM sodium chloride, pH 7.4, containing 0.02% sodium azide.
IMMUNOGEN: Recombinant human SEL1L (suppressor of lin-12-like protein).
SPECIFICITY: Recognizes human and mouse SEL1L.
APPLICATION: Immunohistochemistry (frozen sections; paraffin sections)
Immunoprecipitation
Western Blot (10µg/ml)
Optimal conditions must be determined individually for each application.
SHIPPING: SHIPPED ON BLUE ICE
LONG TERM STORAGE: +4°C
HANDLING: Do not freeze.
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Product Specific Literature References
Production of a monoclonal antibody directed against the recombinant SEL1L protein: R. Orlandi, et al.; J. Biol. Markers 17, 104 (2002) Abstract
SEL1L expression decreases breast tumor cell aggressiveness in vivo and in vitro: R. Orlandi, et al.; Cancer Res. 62, 567 (2002) Abstract; Full Text
General Information
SEL1L (suppressor of lin-12-like protein) is the human ortholog of the C. elegans sel-1 gene, a negative regulator of the lin-12/Notch family of proteins. Human SEL1L is a component of endoplasmic reticulum-associated degradation (ERAD), involved in ubiquitin-dependent degradation of misfolded ER proteins. In addition, SEL1L plays a role in cancer progression. Several studies provided significant evidence that increased SEL1L expression is linked to a decrease in tumor aggressiveness.
General Literature References
Complete cDNA sequence and genomic organization of a human pancreas-specific gene homologous to Caenorhabditis elegans sel-1: Y. Harada, et al.; J. Hum. Genet. 44, 330 (1999) Abstract
SEL1L a multifaceted protein playing a role in tumor progression: I. Biunno, et al.; J. Cell Physiol. 208, 23 (2006) Abstract
A different pathway in the endoplasmic reticulum stress-induced expression of human HRD1 and SEL1 genes: M. Kaneko, et al.; FEBS Lett. 581, 5355 (2007) Abstract
Further Categories Containing This Product:
Monoclonal Antibodies
 
 
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