ALEXIS Biochemicals: MGD . sodium salt . monohydrate

ALX-400-014

Revised 29-Jul-08

MGD . sodium salt . monohydrate
SYNONYMS	N-(Dithiocarbamoyl)-N-methyl-D-glucamine . Na . H₂0
PRODUCT LINE	Oxidative Stress
PRODUCT CATEGORY	Spin Traps, Spin Probes & Spin Labels

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-400-014-M050		50 mg	50.00 USD
ALX-400-014-M250		250 mg	150.00 USD

Product Specification

FORMULA:	C₈H₁₆NO₅S₂Na . H₂O
MW:	293.3 . 18.0
PURITY:	≥99% (¹H-NMR)
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Protect from light.

Product Description

Together with FeSO₄ MGD is a useful component for the formation of the MGD₂-Fe²⁺complex, which is an excellent nitric oxide (NO) spin-trapping reagent. The MGD₂-Fe2+complex is quite unstable, especially in the presence of dissolved oxygen. Thus, the complex should be used immediately after being made. An excess (usually 5-fold excess), of MGD to Fe2+ is used for making the complex with FeSO₄to give a more stable complex solution. Acidic conditions should be avoided because dithiocarbamate tends to decompose forming toxic carbon disulfide. It was reported that MGD and Fe(MGD)₂do not exhibit toxicity up to 8mmol/kg and 0.3mmol/kg, respectively.

Product Specific Literature References

Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication: L.A. Shinobu, et al.; Acta Pharmacol. Toxicol. 54, 189 (1984) Abstract
In vivo spin trapping of nitric oxide in mice: A. Komarov, et al.; BBRC 195, 1191 (1993) Abstract
Spin trapping of nitric oxide produced in vivo in septic-shock mice: C.-S. Lei & A.M. Komarov; FEBS Lett. 345, 120 (1994) Abstract
Spin trapping isotopically-labelled nitric oxide produced from [15N]L- arginine and [17O]dioxygen by activated macrophages using a water soluble Fe(++)-dithiocarbamate spin trap: Y. Kotake, et al.; Free Rad. Res. 23, 287 (1995) Abstract
Continuous and quantitative monitoring of rate of cellular nitric oxide generation: Y. Kotake; Methods Enzymol. 268, 222 (1996) Abstract
Continuous monitoring of cellular nitric oxide generation by spin trapping with an iron-dithiocarbamate complex: Y. Kotake, et al.; Biochim. Biophys. Acta 1289, 362 (1996) Abstract
Complexes of Fe2+ with diethyldithiocarbamate or N-methyl-D-glucamine dithiocarbamate as traps of nitric oxide in animal tissues: comparative investigations: V.D. Mikoyan, et al.; Biochim. Biophys. Acta 1336, 225 (1997) Abstract
Redox properties of iron-dithiocarbamates and their nitrosyl derivatives: implications for their use as traps of nitric oxide in biological systems: A.F. Vanin, et al.; Biochim. Biophys. Acta 1474, 365 (2000) Abstract
Electron-paramagnetic resonance spectroscopy using N-methyl-D-glucamine dithiocarbamate iron cannot discriminate between nitric oxide and nitroxyl: implications for the detection of reaction products for nitric oxide synthase: A.M. Komarov, et al.; Free Radic. Biol. Med. 28, 793 (2000) Abstract
Detailed methods for the quantification of nitric oxide in aqueous solutions using either an oxygen monitor or EPR: S. Venkataraman, et al.; Free Radic. Biol. Med. 29, 580 (2000) Abstract
EPR spectroscopy of common nitric oxide - spin trap complexes: S. Nedeianu & T. Pali; Cell. Mol. Biol. Lett. 7, 142 (2002) Abstract
Redox cycling of iron complexes of N-(dithiocarboxy)sarcosine and N-methyl-D-glucamine dithiocarbamate: C. Lu & W.H. Koppenol; Free Radic. Biol. Med. 39, 1581 (2005) Abstract
Evaluation of lipid-based carrier systems and inclusion complexes of diethyldithiocarbamate-iron to trap nitric oxide in biological systems: N. Charlier, et al.; Magn. Reson. Med. 55, 215 (2006) Abstract

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