ALEXIS Biochemicals: Gonyautoxin 2/3 Epimers

ALX-350-307

Revised 05-Apr-08

Gonyautoxin 2/3 Epimers
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Neurotoxins

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-307-C010		10 µg	230.00 USD

Product Specification

FORMULA:	C₁₀H₁₇N₇O₈S
MW:	395.4
CAS NUMBER:	60508-89-6 (GTX II); 60537-65-7 (GTX III)
SOURCE/HOST:	Isolated from Alexandrium tamarense.
CONCENTRATION:	~5.08µg/ml (GTX II); ~1.96µg/ml (GTX III)
PURITY:	≥95%
APPEARANCE:	Liquid. Solution in 0.3M acetic acid.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
HAZARD:	TOXIC.

Product Description

Neurotoxin. Epimeric mixture of gonyautoxin 2 (GTX II, C-11α-hydroxysaxitoxinsulfate) and gonyautoxin 3 (GTX III, C-11β-hydroxysaxitoxinsulfate). Equally potent and selective Na⁺ channel blockers.

Product Specific Literature References

Letter: Structures of gonyautoxin II and III from the East Coast toxic dinoflagellate Gonyaulax tamarensis: Y. Shimizu, et al.; JACS 98, 5414 (1976) Abstract
Gonyautoxin associated with RNA-containing fraction in the toxic scallop digestive gland: M. Kodama, et al.; J. Biochem. 92, 105 (1982) Abstract
Structure and function of voltage-gated sodium channels: E. Marban, et al.; J. Physiol. 508 (Pt 3), 647 (1998) Abstract; Full Text
Toxicokinetics and toxicodynamics of gonyautoxins after an oral toxin dose in cats: D. Andrinolo, et al.; Toxicon 40, 699 (2002) Abstract
The gonyautoxin 2/3 epimers reduces anal tone when injected in the anal sphincter of healthy adults: R. Garrido, et al.; Biol. Res. 37, 395 (2004) Abstract
Gonyautoxin: new treatment for healing acute and chronic anal fissures: R. Garrido, et al.; Dis. Colon Rectum 48, 335 (2005) Abstract

Further Categories Containing This Product:

Na+ Channels • Marine Natural Products

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