ALEXIS Biochemicals: Bafilomycin C1

ALX-380-209

Revised 13-Nov-07

Bafilomycin C1
SYNONYMS	L-681,110A1
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Antibiotics - ATPase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-380-209-M001		1 mg	220.00 USD

Product Specification

FORMULA:	C₃₉H₆₀O₁₂
MW:	720.4
CAS NUMBER:	88979-61-7
SOURCE/HOST:	Isolated from Streptomyces sp. MST-AS5338.
PURITY:	≥95% (HPLC)
APPEARANCE:	White to tan solid.
SOLUBILITY:	Soluble in 100% ethanol, methanol, dimethyl formamide oder DMSO.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	May undergo transformation to methyl ketal on long term storage in methanol. We recommend to use fresh solutions.
HANDLING:	Protect from light.
HAZARD:	TOXIC.

Product Description

Macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H⁺-ATPase. Shows antibacterial, antifungal, insecticidal and antihelmintic activity. Potential antiosteoporotic agent in treating bone lytic diseases.

Product Specific Literature References

Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity: G. Werner, et al.; J. Antibiot. (Tokyo) 37, 110 (1984) Abstract
Purification of vacuolar ATPase with bafilomycin C1 affinity chromatography: T.J. Rautiala, et al.; BBRC 194, 50 (1993) Abstract
Bafilolides, potent inhibitors of the motility and development of the free-living stages of parasitic nematodes: E. Lacey, et al.; Int. J. Parasitol. 25, 349 (1995) Abstract
Structure and function of V-ATPases in osteoclasts: potential therapeutic targets for the treatment of osteolysis: J. Xu, et al.; Histol. Histopathol. 222, 443 (2007) Abstract

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