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ALX-350-103 Revised 18-Sep-06
Rosiglitazone . maleate
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PRODUCT LINE DNA Regulation / Transcription
PRODUCT CATEGORY PPAR Agonists
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-350-103-M025   25 mg 68.00 USD Add To Cart
ALX-350-103-M100   100 mg 200.00 USD Add To Cart
Product Specification
FORMULA: C18H19N3O3S . C4H4O4
MW: 357.4 . 116.1
CAS NUMBER: 155141-29-0
MERCK INDEX: 14: 8265
PURITY: ≥98%
APPEARANCE: White to off-white powder.
SOLUBILITY: Soluble in DMSO, 100% ethanol, methanol or in aqueous buffer, pH 2.3. Solubility decreases with increasing pH in the physiological range.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stable for 2 years after receipt when stored at +4°C.
HAZARD: HARMFUL.

Product Description
Potent insulin sensitizing agent. Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist. Hepatoxic. Antidiabetic.

Not offered in the US.
Product Specific Literature References
Differential activity of rosiglitazone enantiomers at PPAR gamma: D.J. Parks, et al.; Bioorg. Med. Chem. Lett. 8, 3657 (1998) Abstract
Rosiglitazone: J.A. Balfour & G.L. Plosker; Drugs 57, 921 (1999), (Review) Abstract
Differential effects of insulin-sensitizers troglitazone and rosiglitazone on ion currents in rat vascular myocytes: G.A. Knock, et al.; Eur. J. Pharmacol. 368, 103 (1999) Abstract
Rosiglitazone: an agent from the thiazolidinedione class for the treatment of type 2 diabetes: A. Cheng-Lai & A. Levine; Heart Dis. 2, 326 (2000), (Review) Abstract
Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review: J.M. Malinowski & S. Bolesta; Clin. Ther. 22, 1151 (2000), (Review) Abstract
Rosiglitazone (Avandia): hepatic, cardiac and hematological reactions: M. McMorran & D. Vu; CMAJ 165, 82 (2001) Abstract
A review of rosiglitazone in type 2 diabetes mellitus: A.L. Werner & M.T. Travaglini; Pharmacotherapy 21, 1082 (2001), (Review) Abstract
Further Categories Containing This Product:
Antidiabetic Agents/Related Products
 
 
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