ALEXIS Biochemicals: Chelerythrine chloride

ALX-350-008

Revised 02-Oct-07

Chelerythrine chloride
SYNONYMS	1,2-Dimethoxy-N-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium chloride
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Protein Kinase Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-350-008-M001		1 mg	25.00 USD
ALX-350-008-M005		5 mg	75.00 USD
ALX-350-008-M025		25 mg	300.00 USD

Product Specification

FORMULA:	C₂₁H₁₈NO₄Cl
MW:	383.8
CAS NUMBER:	3895-92-9
MERCK INDEX:	14: 2051
RTECS:	FL9200000
SOURCE/HOST:	Synthetic.
PURITY:	≥97% (completely free of biologically active impurities, such as sanguinarine)
APPEARANCE:	Yellow to orange solid.
SOLUBILITY:	Soluble in DMSO, water, 100% ethanol or methanol.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
HAZARD:	HARMFUL.

Product Description

Potent, selective and cell permeable protein kinase C (PKC) inhibitor. Induces apoptosis. BH3 mimetic which inhibits Bcl-X_L function.

Product Specific Literature References

Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.-N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990) Abstract
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990) Abstract
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994) Abstract
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003) Abstract
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006) Abstract
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006) Abstract

Further Categories Containing This Product:

Bcl-2 Family Modulators • PKC Inhibitors • Alkaloids • Natural Products - Apoptosis Inducers & Inhibitors

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