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ALX-450-011 Revised 26-Apr-07
TPEN
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SYNONYMS N,N,N',N'-Tetrakis-(2-pyridylmethyl)ethylenediamine
PRODUCT LINE Signal Transduction
PRODUCT CATEGORY Calcium Chelators / Caged Calcium Chelators
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-450-011-M100   100 mg 95.00 USD Add To Cart
Product Specification
FORMULA: C26H28N6
MW: 424.6
CAS NUMBER: 16858-02-9
PURITY: ≥97%
APPEARANCE: White to off-white solid.
SOLUBILITY: Soluble in dimethyl formamide, DMSO, 100% ethanol or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C

Product Description
An extremely high-affinity chelator of heavy metals, yet with low affinity for Mg2+ and Ca2+. Lipid-soluble, crossing both natural and artificial membranes. TPEN can be used in conjunction with QUIN 2 (Prod. No. ALX-620-006) or QUIN 2/AM (Prod. No. ALX-620-007) to reduce heavy-metal quenching of QUIN 2 fluorescence in cells. Ion specificity: Zn2+>Fe2+>Mn2+>>Ca2+=Mg2+. Induces DNA fragmentation when chelated with Zn2+ and induces apoptosis.
Product Specific Literature References
H. Toftlund & S. Yde-Andersen; Acta Chem. Scand. Ser. A35, 575 (1981)
Cytosolic Ca2+ homeostasis in Ehrlich and Yoshida carcinomas. A new, membrane-permeant chelator of heavy metals reveals that these ascites tumor cell lines have normal cytosolic free Ca2+: P. Arslan, et al.; J. Biol. Chem. 260, 2719 (1985) Abstract; Full Text
Measurement of intracellular cadmium with fluorescent dyes. Further evidence for the role of calcium channels in cadmium uptake [published erratum appears in J Biol Chem 1993 Mar 15;268(8):6064]: P.M. Hinkle, et al.; J. Biol. Chem. 267, 25553 (1992) Abstract; Full Text
TPEN, a transition metal chelator, improves myocardial protection during prolonged ischemia: M. Karck, et al.; J. Heart Lung Transplant 11, 979 (1992) Abstract
Mechanism of reaction of a suggested superoxide-dismutase mimic, Fe(II)- N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine: L. Iuliano, et al.; Arch. Biochem. Biophys. 293, 153 (1992) Abstract
Chelation of intracellular zinc triggers apoptosis in mature thymocytes: M.J. McCabe, et al.; Lab. Invest. 69, 101 (1993) Abstract
Cytotoxic actions of the heavy metal chelator TPEN on NG108-15 neuroblastoma-glioma cells: M. Adler, et al.; Neurotoxicology 20, 571 (1999) Abstract
Depletion of Intracellular Zinc and Copper with TPEN Results in Apoptosis of Cultured Human Retinal Pigment Epithelial Cells: H.J. Hyun, et al.; Invest. Ophthalmol. Vis. Sci. 42, 460 (2001) Abstract
Further Categories Containing This Product:
Apoptosis Inducers & Inhibitors Other Products • Dyes / Stains / Fluorescent Probes / Fluorescent Labels
 
 
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