ALEXIS Biochemicals: 3-(4-Chlorophenyl)quinoxaline-5-carboxamide

ALX-270-486

Revised 15-Jul-08

3-(4-Chlorophenyl)quinoxaline-5-carboxamide
PRODUCT LINE	DNA Regulation / Transcription
PRODUCT CATEGORY	PARP Inhibitors

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-270-486-M005		5 mg	230.00 USD

Product Specification

FORMULA:	C₁₅H₁₀ClN₃O
MW:	283.7
PURITY:	≥95% (HPLC)
APPEARANCE:	Light brown solid.
SOLUBILITY:	Soluble in DMSO (10mg/ml).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	+4°C
HANDLING:	Packaged under inert gas. Protect from light.
HAZARD:	IRRITANT.

Product Description

Potent quinoxaline-based PARP inhibitor with a 5-fold selectivity towards PARP-2 (IC₅₀=7nM) over PARP-1 (IC₅₀=33nM). Brain-permeant. Exhibits good pharmacokinetics.

Product Specific Literature References

Discovery of quinazolinone and quinoxaline derivatives as potent and selective poly(ADP-ribose) polymerase-1/2 inhibitors: A. Iwashita, et al.; FEBS Lett. 579, 1389 (2005) Abstract
Discovery of potent and selective PARP-1 and PARP-2 inhibitors: SBDD analysis via a combination of X-ray structural study and homology modeling: J. Ishida, et al.; Bioorg. Med. Chem. 14, 1378 (2006) Abstract

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