© 2008 Alexis Corporation
ALX-450-006 Revised 07-Apr-08
Ionomycin (free acid)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Ionophores
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-450-006-M001   1 mg 75.00 USD Add To Cart
ALX-450-006-M005   5 mg 290.00 USD Add To Cart
Product Specification
FORMULA: C41H72O9
MW: 709.0
CAS NUMBER: 56092-81-0
SOURCE/HOST: Isolated from Streptomyces conglobatus.
PURITY: ≥90%
APPEARANCE: Pale-yellow oil.
SOLUBILITY: Soluble in DMSO or methanol.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
USE/STABILITY: Stock solutions are stable for 1 year when stored at +4°C.
HANDLING: Protect from light. Keep under inert gas.
HAZARD: HARMFUL.

Product Description
Potent and selective calcium ionophore. Ca2+/ionomycin complex forms between pH 7-9.5 which has intense UV absorption. Induces apoptotic neuronal degeneration in embryonic cortical neurons and cell cycle arrest at G1 phase.
Product Specific Literature References
Characterization of ionomycin as a calcium ionophore: C.M. Liu & T.E. Herman; J. Biol. Chem. 253, 5892 (1978) Abstract; Full Text
Structure of ionomycin - a novel diacidic polyether antibiotic having high affinity for calcium ions: B.K. Toeplitz at al.; JACS 101, 3344 (1979)
Demonstration of a calcium requirement for secretory protein processing and export. Differential effects of calcium and dithiothreitol: G. Kuznetsov, et al.; J. Biol. Chem. 267, 3932 (1992) Abstract; Full Text
Potentiation of calcium- and caffeine-induced calcium release by cyclic ADP-ribose: H.C. Lee; J. Biol. Chem. 268, 293 (1993) Abstract; Full Text
Contrasting effect of transforming growth factor type beta 1 (TGF-beta 1) on proliferation and interleukin-2 receptor expression in activated and rapidly cycling immature (CD3-CD4-CD8-) thymocytes: A. Dupuy d'Angeac, et al.; J. Cell. Physiol. 154, 44 (1993) Abstract
Ca2+ ionophore-induced apoptosis on cultured embryonic rat cortical neurons: N. Takei & Y. Endo; Brain Res. 652, 65 (1994) Abstract
Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis: K.M. Aagaard-Tillery & D.F. Jelinek; J. Immunol. 155, 3297 (1995) Abstract
ctivation of stress response by ionomycin in rat hepatoma cells: A. S. Sreedhar & U. K. Srinivas; J. Cell. Biochem. 86, 154 (2002) Abstract
Ionomycin downregulates beta-catenin/Tcf signaling in colon cancer cell line: C.H. Park, et al.; Carcinogenesis 26, 1929 (2005) Abstract