© 2008 Alexis Corporation
ALX-380-099
Revised 03-Apr-08
Concanamycin C
PRODUCT LINE
Natural Products / Antibiotics
PRODUCT CATEGORY
Antibiotics - ATPase Inhibitors
Ordering Information
Product Numbers:
Format:
Size:
Unit Price:
Quantity:
Add To Cart
ALX-380-099-C100
100 µg
30.00 USD
ALX-380-099-C500
500 µg
90.00 USD
Product Specification
FORMULA:
C
45
H
74
O
13
MW:
823.1
CAS NUMBER:
81552-34-3
RTECS:
GK6887000
SOURCE/HOST:
Isolated from
Streptomyces sp
.
PURITY:
≥96%
APPEARANCE:
White to off-white solid.
SOLUBILITY:
Soluble in chloroform, methanol, acetonitrile or DMSO. Insoluble in water.
SHIPPING:
AMBIENT
LONG TERM STORAGE:
-20°C
HANDLING:
Protect from light.
HAZARD:
VERY TOXIC.
Product Description
Antibiotic. Inhibits vacuolar-type H
+
-ATPase. Potential antiosteoporotic agent. Shows antiviral and immunosuppressive activity. Active against fungi and yeasts.
Product Specific Literature References
Structures of concanamycins B and C:
H. Kinashi, et al.; J. Antibiot. (Tokyo)
35
, 1618 (1982)
Abstract
Isolation and characterization of concanamycins A, B and C:
H. Kinashi, et al.; J. Antibiot. (Tokyo)
37
, 1333 (1984)
Abstract
Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases:
S. Drose, et al.; Biochemistry
32
, 3902 (1993)
Abstract
Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa:
E.J. Bowman, et al.; J. Biol. Chem.
275
, 167 (2000)
Abstract
Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes:
S. Drose, et al.; Biochemistry
40
, 2816 (2001)
Abstract
Further Categories Containing This Product:
Natural Products - Immunomodulators
•
H+-ATPase/Related Products
•
Natural Products - Antiviral/anti-HIV Agents
•
Antibiotics - Antifungal
•
Antitumor Antibiotics
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