ALEXIS Biochemicals: Deoxygalactonojirimycin . hydrochloride

ALX-580-001

Revised 21-May-08

Deoxygalactonojirimycin . hydrochloride
SYNONYMS	Galactostatin . HCl
PRODUCT LINE	Natural Products / Antibiotics
PRODUCT CATEGORY	Natural Products - Other Signal Transduction Pathway Modulators

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-580-001-M001		1 mg	40.00 USD
ALX-580-001-M005		5 mg	150.00 USD

Product Specification

FORMULA:	C₆H₁₃NO₄. HCl
MW:	163.2 . 36.5
CAS NUMBER:	108147-54-2
SOURCE/HOST:	Synthetic.
PURITY:	≥98%
APPEARANCE:	Lyophilized.
SOLUBILITY:	Soluble in water.
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C

Product Description

Potent and selective α-D-galactosidase inhibitor. Small molecule chemical chaperone.

Product Specific Literature References

Monosaccharides Containing Nitrogen in the Ring, XXXVII. Synthesis of 1,5-Dideoxy-1,5-imino-D-galactitol: H. Paulsen, et al.; Chem. Ber. 113, 2601 (1980)
Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases: G. Legler & S. Pohl; Carbohydr. Res. 155, 119 (1986) Abstract
In vitro inhibition and intracellular enhancement of lysosomal alpha-galactosidase A activity in Fabry lymphoblasts by 1-deoxygalactonojirimycin and its derivatives: N. Asano, et al.; Eur. J. Biochem. 267, 4179 (2000) Abstract
A synthetic chaperone corrects the trafficking defect and disease phenotype in a protein misfolding disorder: G.H. Yam, et al.; FASEB J. 19, 12 (2005) Abstract
Active-site-specific chaperone therapy for Fabry disease. Yin and Yang of enzyme inhibitors: J. Q. Fan & S. Ishii; FEBS J. 274, 4962 (2007) Abstract

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