ALEXIS Biochemicals: N6,O2’-Dibutyryladenosine 3’,5’-cyclic Monophosphate . sodium salt

ALX-480-045

Revised 23-Jan-08

N6,O2’-Dibutyryladenosine 3’,5’-cyclic Monophosphate . sodium salt
SYNONYMS	Dibutyryl-cAMP . Na cAMP, DB-, . Na Bucladesine . Na
PRODUCT LINE	Signal Transduction
PRODUCT CATEGORY	cAMP Derivatives

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-480-045-M005		5 mg	25.00 USD
ALX-480-045-M025		25 mg	75.00 USD

Product Specification

FORMULA:	C₁₈H₂₃N₅O₈P . Na
MW:	468.4 . 23.0
CAS NUMBER:	16980-89-5
PURITY:	≥97%
APPEARANCE:	White lyophilized solid.
SOLUBILITY:	Soluble in water (200mM), DMSO (200mM) or 96% ethanol (25mM).
SHIPPING:	AMBIENT
LONG TERM STORAGE:	-20°C
USE/STABILITY:	Solutions must be stored in the refrigerator and should be lyophilized and frozen for longer storage periods.

Product Description

Membrane permeable activator of cAMP-dependent protein kinase (cAMP agonist). The product releases butyrate due to intracellular and extracellular esterase action. Butyrate was shown to have distinct biological effects.

Product Specific Literature References

Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer & J.P. Miller; Life Sci. 14, 1019 (1974) Abstract
The preparation of acylated derivatives of cyclic nucleotides: T. Posternak & G. Weimann; Meth. Enzymol. 38, 399 (1974) Abstract
Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs: Y.-J. Hei, et al.; Mol. Pharmacol. 39, 233 (1991) Abstract
Up-regulation of oxytocin receptors in rabbit amnion by adenosine 3',5'- monophosphate: A. Hinko and M.S. Soloff; Endocrinology 132, 126 (1993) Abstract
Transcription of the gene for parathyroid hormone-related peptide from the human is activated through a cAMP-dependent pathway by prostaglandin E1 in HTLV-I-infected T cells: K. Ikeda, et al.; J. Biol. Chem. 268, 1174 (1993) Abstract; Full Text
Apoptosis of vascular smooth muscle cells. Protein kinase C and oncoprotein Bcl-2 are involved in regulation of apoptosis in non- transformed rat vascular smooth muscle cells: D. Leszczynski, et al.; Am. J. Pathol. 145, 1265 (1994) Abstract

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PKA Activators

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