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ALX-380-059 Revised 16-Oct-07
Hygromycin B (liquid)
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PRODUCT LINE Natural Products / Antibiotics
PRODUCT CATEGORY Antibiotics - Antiviral / Anti-HIV
Ordering Information
Product Numbers: Format: Size: Unit Price: Quantity: Add To Cart
ALX-380-059-UM01   1 MU 94.00 USD Add To Cart
Product Specification
FORMULA: C20H37N3O13
MW: 527.5
CAS NUMBER: 31282-04-9
MERCK INDEX: 14: 4852
SOURCE/HOST: Isolated from Streptomyces hygroscopicus.
QUANTITY: 1MU (1 million units) in 2.15ml. 350-450mg hygromycin B/ml.
PURITY: ≥80%
APPEARANCE: Dark brown solution.
SHIPPING: AMBIENT
LONG TERM STORAGE: +4°C
HANDLING: Protect from light.
HAZARD: TOXIC.

Product Description
Sterile and ready-to-use antibiotic with high activity. Inhibits growth of prokaryotic and eukaryotic microorganisms and mammalian cells. Inhibits protein synthesis at the translocation step on the 70S ribosome and causes misreading of the mRNA. Penetrates cells that have been permeabilized by virus infection, hence it can act as an effective antiviral agent.
Product Specific Literature References
The Isolation of a Second Antibiotic from Streptomyces hygroscopicus: R. L. Mann & W. W. Bromer; J. Am. Chem. Soc. 80, 2714 (1958)
Antiviral effects of hygromycin B, a translation inhibitor nonpermeant to uninfected cells: J. C. Lacal & L. Carrasco; Antimicrob. Agents Chemother. 24, 273 (1983) Abstract
Induction of p53-independent apoptosis by hygromycin B: suppression by Bcl-2 and adenovirus E1B 19-kDa protein: G. Chen, et al.; Exp. Cell Res. 221, 55 (1995) Abstract
The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit:: D.E. Brodersen, et al.; Cell 103, 1143 (2000) Abstract
A ribosomal ATPase is a target for hygromycin B inhibition on Escherichia coli ribosomes: M. C. Ganoza & M. C. Kiel; Antimicrob. Agents Chemother. 45, 2813 (2001) Abstract
Hygromycin B inhibition of protein synthesis and ribosome biogenesis in Escherichia coli: S. M. McGaha & W. S. Champney; Antimicrob. Agents Chemother. 51, 591 (2007) Abstract
General Information
BACKGROUND/TECHNICAL INFORMATION Microbiological assay: 350'000-500'000U/ml.
Further Categories Containing This Product:
Protein Synthesis Other Products
 
 
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