ALEXIS Biochemicals: Oleoylethanolamide

ALX-300-150

Revised 11-Oct-07

Oleoylethanolamide
SYNONYMS	N-(2-Hydroxyethyl)-9Z-octadecenamide OEA
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	TRPV1 Agonists and Antagonists/Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
ALX-300-150-M005		5 mg	30.00 USD

Product Specification

FORMULA:	C₂₀H₃₉NO₂
MW:	325.5
CAS NUMBER:	111-58-0
PURITY:	≥99%
APPEARANCE:	White to off-white solid.
SOLUBILITY:	Soluble in DMSO, 100% ethanol or methanol.
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C
HANDLING:	Protect from light.
HAZARD:	IRRITANT.

Product Description

Activates TRPV1. Does not activate cannabinoid receptors (CB) but is a PPARα agonist (EC₅₀=120nM) in vitro and in vivo; induces satiety through activation of PPARα. Inhibits ceramidase.

Product Specific Literature References

Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor: L. Hanus, et al.; J. Med. Chem. 36, 3032 (1993) Abstract
Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation: E. Coroneos, et al.; J. Biol. Chem. 270, 23305 (1995) Abstract
Cannabinomimetic behavioral effects of and adenylate cyclase inhibition by two new endogenous anandamides: J. Barg, et al.; Eur. J. Pharmacol. 287, 145 (1995) Abstract
A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding: R. Gomez, et al.; J. Neurosci. 22, 9612 (2002) Abstract
Activation of TRPV1 by the satiety factor oleoylethanolamide: G.P. Ahern; J. Biol. Chem. 278, 30429 (2003) Abstract
Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha: J. Fu, et al.; Nature 425, 90 (2003) Abstract
Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor PPAR-alpha: M. Guzman, et al.; J. Biol. Chem. 279, 27849 (2004)

Further Categories Containing This Product:

Anandamide & Anandamide Analogs • PPAR Agonists

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